Clostridium difficile infection in Italian urban hospitals: Data from 2006 through 2011

Stefano Di Bella, Maria Musso, Maria A. Cataldo, Marcello Meledandri, Eugenio Bordi, Daniela Capozzi, Maria C. Cava, Patrizia Chiaradonna, Grazia Prignano, Nicola Petrosillo

Research output: Contribution to journalArticlepeer-review


Background: In developed countries, Clostridium difficile infection (CDI) represents an emerging threat in terms of morbidity and mortality rates. In our country limited CDI epidemiological data can be found.We have conducted a 6-year retrospective study to evaluate the incidence of CDI in Italian urban hospitals.Methods: Stool samples tested for C. difficile toxins from January 2006 to December 2011 in 5 large hospitals in Rome, Italy, were considered in the analysis. Repeated samples taken ≤ 2 months after a positive result were excluded.Results: A total of 402 CDI episodes were identified. The incidence of CDI episodes progressively increased from 0.3 in 2006 to 2.3 per 10,000 patient-days in 2011. CDI episodes mostly occurred in patients > 60 years of age (77%). The >80 year-old age class reported the highest percentage of CDI episodes on tested samples (16%). Eighty percent (80%) of CDI episodes occurred in medical wards followed by surgery (10.2%) and intensive care units (9.8%).Conclusions: A significant increasing incidence of CDI episodes over the study period was observed during the years (p

Original languageEnglish
Article number146
JournalBMC Infectious Diseases
Issue number1
Publication statusPublished - Mar 22 2013


  • Clostridium difficile
  • Epidemiology
  • Europe
  • Hospitals
  • Incidence
  • Italy

ASJC Scopus subject areas

  • Infectious Diseases


Dive into the research topics of 'Clostridium difficile infection in Italian urban hospitals: Data from 2006 through 2011'. Together they form a unique fingerprint.

Cite this