Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

C. Fiorentini, G. Donelli, P. Nicotera, M. Thelestam

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

Original languageEnglish
Pages (from-to)3988-3993
Number of pages6
JournalInfection and Immunity
Volume61
Issue number9
Publication statusPublished - 1993

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Protein Synthesis Inhibitors
Blister
Population
Clostridium difficile tcdA protein

ASJC Scopus subject areas

  • Immunology

Cite this

Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells. / Fiorentini, C.; Donelli, G.; Nicotera, P.; Thelestam, M.

In: Infection and Immunity, Vol. 61, No. 9, 1993, p. 3988-3993.

Research output: Contribution to journalArticle

Fiorentini, C, Donelli, G, Nicotera, P & Thelestam, M 1993, 'Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells', Infection and Immunity, vol. 61, no. 9, pp. 3988-3993.
Fiorentini, C. ; Donelli, G. ; Nicotera, P. ; Thelestam, M. / Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells. In: Infection and Immunity. 1993 ; Vol. 61, No. 9. pp. 3988-3993.
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