Abstract
In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.
| Original language | English |
|---|---|
| Pages (from-to) | 3988-3993 |
| Number of pages | 6 |
| Journal | Infection and Immunity |
| Volume | 61 |
| Issue number | 9 |
| Publication status | Published - 1993 |
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ASJC Scopus subject areas
- Immunology
Cite this
Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells. / Fiorentini, C.; Donelli, G.; Nicotera, P.; Thelestam, M.
In: Infection and Immunity, Vol. 61, No. 9, 1993, p. 3988-3993.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells
AU - Fiorentini, C.
AU - Donelli, G.
AU - Nicotera, P.
AU - Thelestam, M.
PY - 1993
Y1 - 1993
N2 - In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.
AB - In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.
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UR - http://www.scopus.com/inward/citedby.url?scp=0027250397&partnerID=8YFLogxK
M3 - Article
C2 - 8359922
AN - SCOPUS:0027250397
VL - 61
SP - 3988
EP - 3993
JO - Infection and Immunity
JF - Infection and Immunity
SN - 0019-9567
IS - 9
ER -