Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

C. Fiorentini, G. Donelli, P. Nicotera, M. Thelestam

Research output: Contribution to journalArticlepeer-review

Abstract

In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

Original languageEnglish
Pages (from-to)3988-3993
Number of pages6
JournalInfection and Immunity
Volume61
Issue number9
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Immunology

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