Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

C. Fiorentini; G. Donelli; P. Nicotera; M. Thelestam

Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

C. Fiorentini, G. Donelli, P. Nicotera, M. Thelestam

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca²⁺ independent and were not abolished by protein synthesis inhibitors.

Original language	English
Pages (from-to)	3988-3993
Number of pages	6
Journal	Infection and Immunity
Volume	61
Issue number	9
Publication status	Published - 1993

ASJC Scopus subject areas

Immunology

Cite this

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title = "Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells",

abstract = "In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.",

author = "C. Fiorentini and G. Donelli and P. Nicotera and M. Thelestam",

year = "1993",

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T1 - Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

AU - Fiorentini, C.

AU - Donelli, G.

AU - Nicotera, P.

AU - Thelestam, M.

PY - 1993

Y1 - 1993

N2 - In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

AB - In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

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JO - Infection and Immunity

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SN - 0019-9567

IS - 9

ER -

Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

Abstract

ASJC Scopus subject areas

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