Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

C. Fiorentini; G. Donelli; P. Nicotera; M. Thelestam

Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

C. Fiorentini, G. Donelli, P. Nicotera, M. Thelestam

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca²⁺ independent and were not abolished by protein synthesis inhibitors.

Original language	English
Pages (from-to)	3988-3993
Number of pages	6
Journal	Infection and Immunity
Volume	61
Issue number	9
Publication status	Published - 1993

ASJC Scopus subject areas

Immunology

Fingerprint Dive into the research topics of 'Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells'. Together they form a unique fingerprint.

Cite this

@article{3bfd5caab6344c4990026fdfe288ed37,

title = "Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells",

abstract = "In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.",

author = "C. Fiorentini and G. Donelli and P. Nicotera and M. Thelestam",

year = "1993",

language = "English",

volume = "61",

pages = "3988--3993",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "9",

}

TY - JOUR

T1 - Clostridium difficile toxin A elicits Ca2+-independent cytotoxic effects in cultured normal rat intestinal crypt cells

AU - Fiorentini, C.

AU - Donelli, G.

AU - Nicotera, P.

AU - Thelestam, M.

PY - 1993

Y1 - 1993

N2 - In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

AB - In rat intestinal crypt cells, Clostridium difficile toxin A induces (i) early cytoskeletal alterations involving the whole population and (ii) late effects in 30 to 40% of the cells, consisting mainly of surface blebbing and nuclear fragmentation. All these effects were Ca2+ independent and were not abolished by protein synthesis inhibitors.

UR - http://www.scopus.com/inward/record.url?scp=0027250397&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027250397&partnerID=8YFLogxK

M3 - Article

C2 - 8359922

AN - SCOPUS:0027250397

VL - 61

SP - 3988

EP - 3993

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 9

ER -