Clostridium difficile toxins A and B: Insights into pathogenic properties and extraintestinal effects

Stefano Di Bella, Paolo Ascenzi, Steven Siarakas, Nicola Petrosillo, Alessandra di Masi

Research output: Contribution to journalArticlepeer-review

Abstract

Clostridium difficile infection (CDI) has significant clinical impact especially on the elderly and/or immunocompromised patients. The pathogenicity of Clostridium difficile is mainly mediated by two exotoxins: Toxin A (TcdA) and toxin B (TcdB). These toxins primarily disrupt the cytoskeletal structure and the tight junctions of target cells causing cell rounding and ultimately cell death. Detectable C. difficile toxemia is strongly associated with fulminant disease. However, besides the well-known intestinal damage, recent animal and in vitro studies have suggested a more far-reaching role for these toxins activity including cardiac, renal, and neurologic impairment. The creation of C. difficile strains with mutations in the genes encoding toxin A and B indicate that toxin B plays a major role in overall CDI pathogenesis. Novel insights, such as the role of a regulator protein (TcdE) on toxin production and binding interactions between albumin and C. difficile toxins, have recently been discovered and will be described. Our review focuses on the toxin-mediated pathogenic processes of CDI with an emphasis on recent studies.

Original languageEnglish
Article number134
JournalToxins
Volume8
Issue number5
DOIs
Publication statusPublished - May 1 2016

Keywords

  • Clostridium difficile
  • Pathogenesis
  • Toxins

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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