Clotting activation after transjugular intrahepatic portosystemic stent shunt

Stefania Basili; Manuela Merli; Domenico Ferro; Raffaella Lionetti; Elisabetta Rossi; Oliviero Riggio; Valentina Valeriano; Livio Capocaccia; Francesco Violi

Clotting activation after transjugular intrahepatic portosystemic stent shunt

Stefania Basili, Manuela Merli, Domenico Ferro, Raffaella Lionetti, Elisabetta Rossi, Oliviero Riggio, Valentina Valeriano, Livio Capocaccia, Francesco Violi

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Aim. Aim of the study was to investigate the behaviour of clotting system in peripheral circulation of cirrhotic patients undergoing transjugular intrahepatic portosystemic stent shunt (TIPS). Methods. Clotting variables and endotoxemia were measured 48 h and 30 days after TIPS in patients randomised to receive heparin or not. Results. Forty-eight hours after TIPS, a significant increase of prothrombin fragment F1 + 2 was observed, such increase was less evident in patients given heparin. Similar findings were observed for endotoxemia, which, however, was not affected by heparin treatment. Thirty days after TIPS procedure prothrombin fragment F1 + 2 and endotoxemia returned to baseline values independently of the treatment given. Conclusion. This study shows that TIPS is associated with an increase of clotting activation which might contribute to acute thrombosis observed after this procedure.

Original language	English
Pages (from-to)	711-714
Number of pages	4
Journal	Thrombosis and Haemostasis
Volume	81
Issue number	5
Publication status	Published - 1999

ASJC Scopus subject areas

Hematology

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Clotting activation after transjugular intrahepatic portosystemic stent shunt. / Basili, Stefania; Merli, Manuela; Ferro, Domenico; Lionetti, Raffaella; Rossi, Elisabetta; Riggio, Oliviero; Valeriano, Valentina; Capocaccia, Livio; Violi, Francesco.

In: Thrombosis and Haemostasis, Vol. 81, No. 5, 1999, p. 711-714.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background and Aim. Aim of the study was to investigate the behaviour of clotting system in peripheral circulation of cirrhotic patients undergoing transjugular intrahepatic portosystemic stent shunt (TIPS). Methods. Clotting variables and endotoxemia were measured 48 h and 30 days after TIPS in patients randomised to receive heparin or not. Results. Forty-eight hours after TIPS, a significant increase of prothrombin fragment F1 + 2 was observed, such increase was less evident in patients given heparin. Similar findings were observed for endotoxemia, which, however, was not affected by heparin treatment. Thirty days after TIPS procedure prothrombin fragment F1 + 2 and endotoxemia returned to baseline values independently of the treatment given. Conclusion. This study shows that TIPS is associated with an increase of clotting activation which might contribute to acute thrombosis observed after this procedure.",

author = "Stefania Basili and Manuela Merli and Domenico Ferro and Raffaella Lionetti and Elisabetta Rossi and Oliviero Riggio and Valentina Valeriano and Livio Capocaccia and Francesco Violi",

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T1 - Clotting activation after transjugular intrahepatic portosystemic stent shunt

AU - Basili, Stefania

AU - Merli, Manuela

AU - Ferro, Domenico

AU - Lionetti, Raffaella

AU - Rossi, Elisabetta

AU - Riggio, Oliviero

AU - Valeriano, Valentina

AU - Capocaccia, Livio

AU - Violi, Francesco

PY - 1999

Y1 - 1999

N2 - Background and Aim. Aim of the study was to investigate the behaviour of clotting system in peripheral circulation of cirrhotic patients undergoing transjugular intrahepatic portosystemic stent shunt (TIPS). Methods. Clotting variables and endotoxemia were measured 48 h and 30 days after TIPS in patients randomised to receive heparin or not. Results. Forty-eight hours after TIPS, a significant increase of prothrombin fragment F1 + 2 was observed, such increase was less evident in patients given heparin. Similar findings were observed for endotoxemia, which, however, was not affected by heparin treatment. Thirty days after TIPS procedure prothrombin fragment F1 + 2 and endotoxemia returned to baseline values independently of the treatment given. Conclusion. This study shows that TIPS is associated with an increase of clotting activation which might contribute to acute thrombosis observed after this procedure.

AB - Background and Aim. Aim of the study was to investigate the behaviour of clotting system in peripheral circulation of cirrhotic patients undergoing transjugular intrahepatic portosystemic stent shunt (TIPS). Methods. Clotting variables and endotoxemia were measured 48 h and 30 days after TIPS in patients randomised to receive heparin or not. Results. Forty-eight hours after TIPS, a significant increase of prothrombin fragment F1 + 2 was observed, such increase was less evident in patients given heparin. Similar findings were observed for endotoxemia, which, however, was not affected by heparin treatment. Thirty days after TIPS procedure prothrombin fragment F1 + 2 and endotoxemia returned to baseline values independently of the treatment given. Conclusion. This study shows that TIPS is associated with an increase of clotting activation which might contribute to acute thrombosis observed after this procedure.

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