Clozapine-induced hypersensitivity myocarditis

Maurizio Pieroni, Roberto Cavallaro, Cristina Chimenti, Enrico Smeraldi, Andrea Frustaci

Research output: Contribution to journalArticlepeer-review


A rare, but frequently fatal, side effect of the antipsychotic drug clozapine is myocarditis. We report a case of hypersensitivity myocarditis secondary to clozapine administration that was diagnosed in vivo for the first time through endomyocardial biopsy and was successfully treated with corticosteroids. Histologic diagnosis was based on the evidence of eosinophilic infiltration of the endomyocardium and eosinophil degranulation. Endomyocardial biopsy was performed in order to establish or exclude a clear-cut relationship between cardiac dysfunction and clozapine, and was crucial to establish a correct diagnosis and appropriate treatment. Clozapine withdrawal and targeted 8-day, low-dose corticosteroid therapy resolved the symptoms and restored cardiac function.

Original languageEnglish
Pages (from-to)1703-1705
Number of pages3
Issue number5
Publication statusPublished - Nov 2004


  • Differential diagnosis
  • Drug hypersensitivity
  • Endomyocardial biopsy
  • Myocarditis
  • Schizophrenia

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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