TY - JOUR
T1 - Cluster headache and TACs
T2 - state of the art
AU - Giani, Luca
AU - Proietti Cecchini, Alberto
AU - Leone, Massimo
N1 - Funding Information:
LG receives funding from the Italian Ministry of Health (research program RF-2016-02364909). ML received honoraria as advisory board for Eli Lilly and Teva. APC certifies that there is no actual or potential conflict of interest in relation to this article.
Publisher Copyright:
© 2020, Fondazione Società Italiana di Neurologia.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Cluster headache (CH), paroxysmal hemicrania (PH), short-lasting unilateral neuralgiform headache attacks (including SUNCT and SUNA), and hemicrania continua (HC) compose the group of trigeminal autonomic cephalalgias (TACs). Here, we review the recent advances in the field and summarize the current knowledge about the origin of these headaches. Similar to the other primary headaches, the pathogenesis is still much obscure. However, advances are being made in both animal models and humans studies. Three structures clearly appear to be crucial in the pathophysiology of TACs: the trigeminal nerve, the facial parasympathetic system, and the hypothalamus. The physiologic and pathologic functioning of each of these elements and their interactions is being progressively clarified, but critical questions are still open.
AB - Cluster headache (CH), paroxysmal hemicrania (PH), short-lasting unilateral neuralgiform headache attacks (including SUNCT and SUNA), and hemicrania continua (HC) compose the group of trigeminal autonomic cephalalgias (TACs). Here, we review the recent advances in the field and summarize the current knowledge about the origin of these headaches. Similar to the other primary headaches, the pathogenesis is still much obscure. However, advances are being made in both animal models and humans studies. Three structures clearly appear to be crucial in the pathophysiology of TACs: the trigeminal nerve, the facial parasympathetic system, and the hypothalamus. The physiologic and pathologic functioning of each of these elements and their interactions is being progressively clarified, but critical questions are still open.
KW - CGRP
KW - Cluster headache
KW - Headache
KW - PACAP
KW - Trigeminal autonomic cephalalgias
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U2 - 10.1007/s10072-020-04639-4
DO - 10.1007/s10072-020-04639-4
M3 - Review article
C2 - 32845489
AN - SCOPUS:85089885551
VL - 41
SP - 367
EP - 375
JO - Neurological Sciences
JF - Neurological Sciences
SN - 1590-1874
ER -