Cluster headache--course over ten years in 189 patients.

G. C. Manzoni, G. Micieli, F. Granella, C. Tassorelli, C. Zanferrari, A. Cavallini

Research output: Contribution to journalArticle

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Abstract

One-hundred-and-eighty-nine cluster headache patients, referred to Parma and Pavia Headache Centres between 1976 and 1986 with a disease duration of over 10 years, were interviewed about the course of cluster headache. They were classified as episodic (n = 140) or chronic (n = 49) cluster headache patients on the basis of course during the year of onset. Episodic patients showed the following outcome: maintenance of an episodic form (primary episodic form) in 80.7% of cases, shift towards a chronic form (secondary chronic form) in 12.9% and shift towards an intermediate pattern ("combined" form) in 6.4%. In chronic patients, cluster headache was still chronic (primary chronic form) at the moment of observation in 52.4% of cases, while it turned into an episodic form ("secondary" episodic form) in 32.6% and into a "combined" form in 14.3%. Nineteen patients (10%) had had no attacks for at least three years at the moment of examination. We can conclude from our data that: cluster headache is a disease of long duration, perhaps lifelong; episodic cluster headache tends to worsen; chronic cluster headache may easily turn into a better prognostic episodic form; prophylactic drugs are unable to induce recovery. The following factors seem related to a poor outcome: a later onset, the male gender and a disease duration of over 20 years for the episodic forms.

Original languageEnglish
Pages (from-to)169-174
Number of pages6
JournalCephalalgia
Volume11
Issue number4
Publication statusPublished - Sep 1991

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Cluster Headache
Headache
Maintenance
Observation
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology

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Cluster headache--course over ten years in 189 patients. / Manzoni, G. C.; Micieli, G.; Granella, F.; Tassorelli, C.; Zanferrari, C.; Cavallini, A.

In: Cephalalgia, Vol. 11, No. 4, 09.1991, p. 169-174.

Research output: Contribution to journalArticle

Manzoni, GC, Micieli, G, Granella, F, Tassorelli, C, Zanferrari, C & Cavallini, A 1991, 'Cluster headache--course over ten years in 189 patients.', Cephalalgia, vol. 11, no. 4, pp. 169-174.
Manzoni, G. C. ; Micieli, G. ; Granella, F. ; Tassorelli, C. ; Zanferrari, C. ; Cavallini, A. / Cluster headache--course over ten years in 189 patients. In: Cephalalgia. 1991 ; Vol. 11, No. 4. pp. 169-174.
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