Cluster headache: What has changed since 1999?

Massimo Leone, Alberto Proietti Cecchini, Vincenzo Tullo, Marcella Curone, Paola Di Fiore, Gennaro Bussone

Research output: Contribution to journalArticlepeer-review


The peripheral and central origin of pain in cluster headache (CH) and trigeminal autonomic cephalgias (TACs) has been matter of debate. In the last decade, a number of information came from both animal and human studies. This paper briefly highlights main data from these studies. Taken together, there is now sufficient body of evidence indicating that CH and TACs can be regarded as a unique headache spectrum-syndrome, due to involvement of specific brain areas.

Original languageEnglish
JournalNeurological Sciences
Issue numberSUPPL. 1
Publication statusPublished - 2013


  • Cluster headache
  • Hypothalamus
  • Neurostimulation
  • Treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology
  • Medicine(all)


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