Cluster structure of functional networks estimated from high-resolution EGG data

Roberta Sinatra, Fabrizaio De Vico Fallani, Laura Astolfi, Fabio Babiloni, Febo Cincotti, Donatella Mattia, Vito Latora

Research output: Contribution to journalArticlepeer-review

Abstract

We study the topological properties of functional connectivity patterns among cortical areas in the frequency domain. The cortical networks were estimated from high-resolution EEG recordings in a group of spinal cord injured patients and in a group of healthy subjects, during the preparation of a limb movement. We first evaluate global and local efficiency, as indicators of the structural connectivity respectively at a global and local scale. Then, we use the Markov Clustering method to analyze the division of the network into community structures. The results indicate large differences between the injured patients and the healthy subjects. In particular, the networks of spinal cord injured patient exhibited a higher density of efficient clusters. In the Alpha (7-12 Hz) frequency band, the two observed largest communities were mainly composed of the cingulate motor areas with the supplementary motor areas, and of the premotor areas with the right primary motor area of the foot. This functional separation strengthens the hypothesis of a compensative mechanism due to the partial alteration in the primary motor areas because of the effects of the spinal cord injury.

Original languageEnglish
Pages (from-to)665-676
Number of pages12
JournalInternational Journal of Bifurcation and Chaos
Volume19
Issue number2
DOIs
Publication statusPublished - 2009

Keywords

  • Community structure
  • Cortical activity
  • Network efficiency

ASJC Scopus subject areas

  • Applied Mathematics
  • General
  • Engineering(all)
  • Modelling and Simulation

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