Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene

L. Stuppia, V. Gatta, G. Mastroprimiano, F. Pompetti, G. Calabrese, P. Guanciali Franchi, E. Morizio, R. Mingarelli, M. Nicolai, R. Tenaglia, L. Improta, V. Sforza, S. Bisceglia, G. Palka

Research output: Contribution to journalArticle

Abstract

Y chromosome molecular analysis was performed using the STS-PCR technique in 50 patients with oligozoospermia. Microdeletions of interval 6 of the Y chromosome were detected in seven patients, in six of whom subinterval E was affected. All patients retained the RBM1 and DAZ genes, while in one deletion involved the SPGY gene. The size of the deletion was not apparently related to the severity of the disease. These results suggest the presence of an oligozoospermia critical region on the Y chromosome within subinterval E of interval 6.

Original languageEnglish
Pages (from-to)881-883
Number of pages3
JournalJournal of Medical Genetics
Volume34
Issue number11
Publication statusPublished - 1997

Fingerprint

Oligospermia
Y Chromosome
Cluster Analysis
Genes
Polymerase Chain Reaction
Male sterility due to Y-chromosome deletions

Keywords

  • Chromosome deletion
  • Oligozoospermia
  • PCR
  • Y chromosome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Stuppia, L., Gatta, V., Mastroprimiano, G., Pompetti, F., Calabrese, G., Guanciali Franchi, P., ... Palka, G. (1997). Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene. Journal of Medical Genetics, 34(11), 881-883.

Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene. / Stuppia, L.; Gatta, V.; Mastroprimiano, G.; Pompetti, F.; Calabrese, G.; Guanciali Franchi, P.; Morizio, E.; Mingarelli, R.; Nicolai, M.; Tenaglia, R.; Improta, L.; Sforza, V.; Bisceglia, S.; Palka, G.

In: Journal of Medical Genetics, Vol. 34, No. 11, 1997, p. 881-883.

Research output: Contribution to journalArticle

Stuppia, L, Gatta, V, Mastroprimiano, G, Pompetti, F, Calabrese, G, Guanciali Franchi, P, Morizio, E, Mingarelli, R, Nicolai, M, Tenaglia, R, Improta, L, Sforza, V, Bisceglia, S & Palka, G 1997, 'Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene', Journal of Medical Genetics, vol. 34, no. 11, pp. 881-883.
Stuppia, L. ; Gatta, V. ; Mastroprimiano, G. ; Pompetti, F. ; Calabrese, G. ; Guanciali Franchi, P. ; Morizio, E. ; Mingarelli, R. ; Nicolai, M. ; Tenaglia, R. ; Improta, L. ; Sforza, V. ; Bisceglia, S. ; Palka, G. / Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene. In: Journal of Medical Genetics. 1997 ; Vol. 34, No. 11. pp. 881-883.
@article{cee4a4f32a2142cda8f417d6dd35bb50,
title = "Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene",
abstract = "Y chromosome molecular analysis was performed using the STS-PCR technique in 50 patients with oligozoospermia. Microdeletions of interval 6 of the Y chromosome were detected in seven patients, in six of whom subinterval E was affected. All patients retained the RBM1 and DAZ genes, while in one deletion involved the SPGY gene. The size of the deletion was not apparently related to the severity of the disease. These results suggest the presence of an oligozoospermia critical region on the Y chromosome within subinterval E of interval 6.",
keywords = "Chromosome deletion, Oligozoospermia, PCR, Y chromosome",
author = "L. Stuppia and V. Gatta and G. Mastroprimiano and F. Pompetti and G. Calabrese and {Guanciali Franchi}, P. and E. Morizio and R. Mingarelli and M. Nicolai and R. Tenaglia and L. Improta and V. Sforza and S. Bisceglia and G. Palka",
year = "1997",
language = "English",
volume = "34",
pages = "881--883",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "BMJ Publishing Group",
number = "11",

}

TY - JOUR

T1 - Clustering of Y chromosome deletions in subinterval E of interval 6 supports the existence of an oligozoospermia critical region outside the DAZ gene

AU - Stuppia, L.

AU - Gatta, V.

AU - Mastroprimiano, G.

AU - Pompetti, F.

AU - Calabrese, G.

AU - Guanciali Franchi, P.

AU - Morizio, E.

AU - Mingarelli, R.

AU - Nicolai, M.

AU - Tenaglia, R.

AU - Improta, L.

AU - Sforza, V.

AU - Bisceglia, S.

AU - Palka, G.

PY - 1997

Y1 - 1997

N2 - Y chromosome molecular analysis was performed using the STS-PCR technique in 50 patients with oligozoospermia. Microdeletions of interval 6 of the Y chromosome were detected in seven patients, in six of whom subinterval E was affected. All patients retained the RBM1 and DAZ genes, while in one deletion involved the SPGY gene. The size of the deletion was not apparently related to the severity of the disease. These results suggest the presence of an oligozoospermia critical region on the Y chromosome within subinterval E of interval 6.

AB - Y chromosome molecular analysis was performed using the STS-PCR technique in 50 patients with oligozoospermia. Microdeletions of interval 6 of the Y chromosome were detected in seven patients, in six of whom subinterval E was affected. All patients retained the RBM1 and DAZ genes, while in one deletion involved the SPGY gene. The size of the deletion was not apparently related to the severity of the disease. These results suggest the presence of an oligozoospermia critical region on the Y chromosome within subinterval E of interval 6.

KW - Chromosome deletion

KW - Oligozoospermia

KW - PCR

KW - Y chromosome

UR - http://www.scopus.com/inward/record.url?scp=16944363366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16944363366&partnerID=8YFLogxK

M3 - Article

C2 - 9391878

AN - SCOPUS:16944363366

VL - 34

SP - 881

EP - 883

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

SN - 0022-2593

IS - 11

ER -