Abstract
Many human papillomavirus (HPV) infections are sustained by multiple viral genotypes whose effect on the risk of cervical intraepithelial neoplasia (CIN) is unknown. The study investigated whether specific HPV types or species may affect the likelihood of multiple infections and have a clustered distribution in a consecutive series of 681 women with a histological diagnosis of CIN. HPV typing was performed by the SPF10-LIPA assay; associations were evaluated by loglinear analysis of multiple contingency tables after stratification by age and CIN grade. HPV prevalence was 99.4% with a 72.1% rate of coinfection. The risk of coinfection was higher for types 6, 11, 16, 18, 31, 33, 51, 52, 56. Significant interactions were found for species A7-A9-A10, A6-A9 and A7-A10. Coinfection by types 31-35-56, 16-51-52, 16-18 and 51-52 was more frequent than expected. Interactions between viral species and HPV 16-18 were maintained among CIN1, whereas interactions of 16-51-52 and 31-51-56 were significant only in CIN ≥ 2. Interactions between species and types were lost among women younger than 32 years. Significant clustering of HPV types and species occurs among women with CIN. This has implications for the assessment of the oncogenic potential and the prevention of HPV infections.
| Original language | English |
|---|---|
| Pages (from-to) | 154-159 |
| Number of pages | 6 |
| Journal | Virus Research |
| Volume | 142 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jun 2009 |
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Keywords
- Cancer
- Cervical intraepithelial neoplasia (CIN)
- Cervix
- Coinfection
- Human papillomavirus (HPV)
- Squamous intraepithelial lesion (SIL)
ASJC Scopus subject areas
- Virology
- Infectious Diseases
- Cancer Research
Cite this
Clustering patterns of human papillomavirus genotypes in multiple infections. / Spinillo, Arsenio; Dal Bello, Barbara; Alberizzi, Paola; Cesari, Stefania; Gardella, Barbara; Roccio, Marianna; Silini, Enrico Maria.
In: Virus Research, Vol. 142, No. 1-2, 06.2009, p. 154-159.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Clustering patterns of human papillomavirus genotypes in multiple infections
AU - Spinillo, Arsenio
AU - Dal Bello, Barbara
AU - Alberizzi, Paola
AU - Cesari, Stefania
AU - Gardella, Barbara
AU - Roccio, Marianna
AU - Silini, Enrico Maria
PY - 2009/6
Y1 - 2009/6
N2 - Many human papillomavirus (HPV) infections are sustained by multiple viral genotypes whose effect on the risk of cervical intraepithelial neoplasia (CIN) is unknown. The study investigated whether specific HPV types or species may affect the likelihood of multiple infections and have a clustered distribution in a consecutive series of 681 women with a histological diagnosis of CIN. HPV typing was performed by the SPF10-LIPA assay; associations were evaluated by loglinear analysis of multiple contingency tables after stratification by age and CIN grade. HPV prevalence was 99.4% with a 72.1% rate of coinfection. The risk of coinfection was higher for types 6, 11, 16, 18, 31, 33, 51, 52, 56. Significant interactions were found for species A7-A9-A10, A6-A9 and A7-A10. Coinfection by types 31-35-56, 16-51-52, 16-18 and 51-52 was more frequent than expected. Interactions between viral species and HPV 16-18 were maintained among CIN1, whereas interactions of 16-51-52 and 31-51-56 were significant only in CIN ≥ 2. Interactions between species and types were lost among women younger than 32 years. Significant clustering of HPV types and species occurs among women with CIN. This has implications for the assessment of the oncogenic potential and the prevention of HPV infections.
AB - Many human papillomavirus (HPV) infections are sustained by multiple viral genotypes whose effect on the risk of cervical intraepithelial neoplasia (CIN) is unknown. The study investigated whether specific HPV types or species may affect the likelihood of multiple infections and have a clustered distribution in a consecutive series of 681 women with a histological diagnosis of CIN. HPV typing was performed by the SPF10-LIPA assay; associations were evaluated by loglinear analysis of multiple contingency tables after stratification by age and CIN grade. HPV prevalence was 99.4% with a 72.1% rate of coinfection. The risk of coinfection was higher for types 6, 11, 16, 18, 31, 33, 51, 52, 56. Significant interactions were found for species A7-A9-A10, A6-A9 and A7-A10. Coinfection by types 31-35-56, 16-51-52, 16-18 and 51-52 was more frequent than expected. Interactions between viral species and HPV 16-18 were maintained among CIN1, whereas interactions of 16-51-52 and 31-51-56 were significant only in CIN ≥ 2. Interactions between species and types were lost among women younger than 32 years. Significant clustering of HPV types and species occurs among women with CIN. This has implications for the assessment of the oncogenic potential and the prevention of HPV infections.
KW - Cancer
KW - Cervical intraepithelial neoplasia (CIN)
KW - Cervix
KW - Coinfection
KW - Human papillomavirus (HPV)
KW - Squamous intraepithelial lesion (SIL)
UR - http://www.scopus.com/inward/record.url?scp=67349232293&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67349232293&partnerID=8YFLogxK
U2 - 10.1016/j.virusres.2009.02.004
DO - 10.1016/j.virusres.2009.02.004
M3 - Article
C2 - 19428748
AN - SCOPUS:67349232293
VL - 142
SP - 154
EP - 159
JO - Virus Research
JF - Virus Research
SN - 0168-1702
IS - 1-2
ER -