CMV and BKV ureteritis: Which prognosis for the renal graft?

Fabio Fusaro, Luisa Murer, Franco Busolo, Waifro Rigamonti, Giovanni F. Zanon, Graziella Zacchello

Research output: Contribution to journalArticle

Abstract

This report describes two cases of ureteral stricture in renal graft recipients related to cytomegalovirus (CMV) and human polyoma BK virus (BKV) ureteritis with the same onset characterized by acute graft failure with no clinical signs of systemic viral infections. The histological analysis did not show other causes of graft impairment (i.e. drug toxicity and acute rejection). Ultrasound scan (US) revealed absent or mild hydronephrosis. The diuretic-MAG3 renal scan showed a urinary flow obstruction. The viral genomes were isolated from urine, peripheral blood and graft or ureteral tissues samples. A percutaneous nephrostomy confirmed the stricture, but it restored urine flow only in the graft affected by CMV ureteritis, the association with a specific antiviral therapy probably produced a stable restoration of graft function. In BKV ureteritis, the graft prognosis was poor; graft loss could be due to the progress of BKV nephropathy. A correct differential diagnosis of the etiologic agent responsible for the ureteritis is mandatory, because treatment and outcome of the infection are different.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalJournal of Nephrology
Volume16
Issue number4
Publication statusPublished - Jul 2003

Keywords

  • BK polyomavirus
  • Cytomegalovirus
  • Renal transplantation
  • Viral ureteritis

ASJC Scopus subject areas

  • Nephrology

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  • Cite this

    Fusaro, F., Murer, L., Busolo, F., Rigamonti, W., Zanon, G. F., & Zacchello, G. (2003). CMV and BKV ureteritis: Which prognosis for the renal graft? Journal of Nephrology, 16(4), 591-594.