Co-administration of H-ferritin-doxorubicin and Trastuzumab in neoadjuvant setting improves efficacy and prevents cardiotoxicity in HER2 + murine breast cancer model

F. Andreata, A. Bonizzi, M. Sevieri, M. Truffi, M. Monieri, L. Sitia, F. Silva, L. Sorrentino, R. Allevi, P. Zerbi, B. Marchini, E. Longhi, R. Ottria, S. Casati, R. Vanna, C. Morasso, M. Bellini, D. Prosperi, F. Corsi, S. Mazzucchelli

Research output: Contribution to journalArticlepeer-review

Abstract

Neoadjuvant chemotherapy has been established as the standard of care for HER2-positive breast cancer since it allows cancer down-staging, up to pathological complete response. The standard of care in the neoadjuvant setting for HER2-positive breast cancer is a combination of highly cytotoxic drugs such as anthracyclines and the anti-HER2 monoclonal antibody. Despite this cocktail allows a pathological complete response in up to 50%, their co-administration is strongly limited by intrinsic cardiotoxicity. Therefore, only a sequential administration of anthracyclines and the anti-HER2 treatment is allowed. Here, we propose the anthracycline formulation in H-Ferritin nanocages as promising candidate to solve this unmet clinical need, thanks to its capability to increase anthracyclines efficacy while reducing their cardiotoxicity. Treating a murine model of HER2-positive breast cancer with co-administration of Trastuzumab and H-Ferritin anthracycline nanoformulation, we demonstrate an improved tumor penetration of drugs, leading to increased anticancer efficacy and reduced of cardiotoxicity.

Original languageEnglish
Article number11425
JournalScientific Reports
Volume10
Issue number1
DOIs
Publication statusPublished - Dec 2020

ASJC Scopus subject areas

  • General

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