Abstract
Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly-morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1β, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.
| Original language | English |
|---|---|
| Pages (from-to) | 715-718 |
| Number of pages | 4 |
| Journal | Journal of Antimicrobial Chemotherapy |
| Volume | 43 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1999 |
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ASJC Scopus subject areas
- Pharmacology
- Microbiology
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Co-amoxiclav affects cytokine production by human polymorphonuclear cells. / Reato, Gigliola; Cuffini, Anna Maria; Tullio, Vivian; Palarchio, Angela Ianni; Bonino, Alessandro; Foa, Roberto; Carlone, Nicola A.
In: Journal of Antimicrobial Chemotherapy, Vol. 43, No. 5, 1999, p. 715-718.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Co-amoxiclav affects cytokine production by human polymorphonuclear cells
AU - Reato, Gigliola
AU - Cuffini, Anna Maria
AU - Tullio, Vivian
AU - Palarchio, Angela Ianni
AU - Bonino, Alessandro
AU - Foa, Roberto
AU - Carlone, Nicola A.
PY - 1999
Y1 - 1999
N2 - Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly-morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1β, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.
AB - Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly-morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1β, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.
UR - http://www.scopus.com/inward/record.url?scp=0032923261&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032923261&partnerID=8YFLogxK
U2 - 10.1093/jac/43.5.715
DO - 10.1093/jac/43.5.715
M3 - Article
C2 - 10382896
AN - SCOPUS:0032923261
VL - 43
SP - 715
EP - 718
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 5
ER -