Co-amoxiclav affects cytokine production by human polymorphonuclear cells

Gigliola Reato, Anna Maria Cuffini, Vivian Tullio, Angela Ianni Palarchio, Alessandro Bonino, Roberto Foa, Nicola A. Carlone

Research output: Contribution to journalArticlepeer-review

Abstract

Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly-morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1β, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.

Original languageEnglish
Pages (from-to)715-718
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume43
Issue number5
DOIs
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

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