Co-amoxiclav affects cytokine production by human polymorphonuclear cells

Gigliola Reato, Anna Maria Cuffini, Vivian Tullio, Angela Ianni Palarchio, Alessandro Bonino, Roberto Foa, Nicola A. Carlone

Research output: Contribution to journalArticle

Abstract

Some antimicrobial agents have been reported to modify the host immune responses both in vivo and in vitro. As we demonstrated previously that co-amoxiclav had beneficial properties which result in enhancement of the microbicidal functions of human poly-morphonuclear cell (PMNs), we investigated the modulatory effect of this combination on cytokine production by human PMNs in vitro. The addition of co-amoxiclav elicited the production by lipopolysaccharide (LPS)-stimulated PMNs of substantial amounts of some cytokines, namely IL-8 and IL-1β, after the addition of Klebsiella pneumoniae. These cytokine levels were higher than those obtained by PMNs incubated in culture medium only, without co-amoxiclav.

Original languageEnglish
Pages (from-to)715-718
Number of pages4
JournalJournal of Antimicrobial Chemotherapy
Volume43
Issue number5
DOIs
Publication statusPublished - 1999

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Amoxicillin-Potassium Clavulanate Combination
Cytokines
Klebsiella pneumoniae
Anti-Infective Agents
Interleukin-8
Interleukin-1
Culture Media
Lipopolysaccharides
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

Cite this

Reato, G., Cuffini, A. M., Tullio, V., Palarchio, A. I., Bonino, A., Foa, R., & Carlone, N. A. (1999). Co-amoxiclav affects cytokine production by human polymorphonuclear cells. Journal of Antimicrobial Chemotherapy, 43(5), 715-718. https://doi.org/10.1093/jac/43.5.715

Co-amoxiclav affects cytokine production by human polymorphonuclear cells. / Reato, Gigliola; Cuffini, Anna Maria; Tullio, Vivian; Palarchio, Angela Ianni; Bonino, Alessandro; Foa, Roberto; Carlone, Nicola A.

In: Journal of Antimicrobial Chemotherapy, Vol. 43, No. 5, 1999, p. 715-718.

Research output: Contribution to journalArticle

Reato, G, Cuffini, AM, Tullio, V, Palarchio, AI, Bonino, A, Foa, R & Carlone, NA 1999, 'Co-amoxiclav affects cytokine production by human polymorphonuclear cells', Journal of Antimicrobial Chemotherapy, vol. 43, no. 5, pp. 715-718. https://doi.org/10.1093/jac/43.5.715
Reato, Gigliola ; Cuffini, Anna Maria ; Tullio, Vivian ; Palarchio, Angela Ianni ; Bonino, Alessandro ; Foa, Roberto ; Carlone, Nicola A. / Co-amoxiclav affects cytokine production by human polymorphonuclear cells. In: Journal of Antimicrobial Chemotherapy. 1999 ; Vol. 43, No. 5. pp. 715-718.
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