Co-electrospun gelatin-poly(L-lactic acid) scaffolds: Modulation of mechanical properties and chondrocyte response as a function of composition

Paola Torricelli, Michela Gioffrè, Andrea Fiorani, Silvia Panzavolta, Chiara Gualandi, Milena Fini, Maria Letizia Focarete, Adriana Bigi

Research output: Contribution to journalArticle

Abstract

Bio-synthetic scaffolds of interspersed poly(l-lactic acid) (PLLA) and gelatin (GEL) fibers are fabricated by co-electrospinning. Tailored PLLA/GEL compositions are obtained and GEL crosslinking with genipin provides for the maintenance of good fiber morphology. Scaffold tensile mechanical properties are intermediate between those of pure PLLA and GEL and vary as a function of PLLA content. Primary human chondrocytes grown on the scaffolds exhibit good proliferation and increased values of the differentiation parameters, especially for intermediate PLLA/GEL compositions. Mineralization tests enable the deposition of a uniform layer of poorly crystalline apatite onto the scaffolds, suggesting potential applications involving cartilage as well as cartilage-bone interface tissue engineering.

Original languageEnglish
Pages (from-to)130-138
Number of pages9
JournalMaterials Science and Engineering C
Volume36
Issue number1
DOIs
Publication statusPublished - Mar 1 2014

Keywords

  • Chondrocytes
  • Electrospun scaffolds
  • Gelatin
  • Mineralization
  • Poly(lactic acid)

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering
  • Mechanics of Materials
  • Medicine(all)

Fingerprint Dive into the research topics of 'Co-electrospun gelatin-poly(L-lactic acid) scaffolds: Modulation of mechanical properties and chondrocyte response as a function of composition'. Together they form a unique fingerprint.

  • Cite this