Co-existence of cutaneous T-cell lymphoma and B hairy cell leukemia

Rossella Paolini, Alessandro Poletti, Emilio Ramazzina, Chiara Menin, Maria Santacatterina, Marco Montagna, Laura Bonaldi, Annarosa Del Mistro, Sergio Zamboni, Emma D'Andrea

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A primary cutaneous form of peripheral T-cell lymphoma (PTCL) and a low grade B-cell non-Hodgkin's lymphoma that was classified as a variant of hairy cell leukemia (HCL) were simultaneously diagnosed in a 79-year-old woman by both phenotypic and genotypic analyses. The coexistence of a T- and B-cell lymphoma in the same patient is rare, and, to our knowledge, this particular association has not been previously described. The patient was referred to our Department for evaluation of multiple cutaneous itchy, reddish plaques; laboratory analyses disclosed a lymphocytosis, that presented 6 years earlier. A bone marrow aspirate showed a 50% B-cell interstitial infiltrate, while a skin biopsy surprisingly revealed a PTCL. Clonality of both neoplastic processes was assessed by Southern blot analysis. The indolent clinical course of the cutaneous disease, and the low and stable number of circulating neoplastic T cells supported the diagnosis of a mycosis fungoides (MF)-Iike PTCL. Possible oncogenic events and/or putative underlying viral infections which could have played a role in the occurrence of B- and T-cell non-Hodgkin's lymphomas in the same patient are discussed. (C) 2000 Wiley- Liss, Inc.

Original languageEnglish
Pages (from-to)197-202
Number of pages6
JournalAmerican Journal of Hematology
Volume64
Issue number3
DOIs
Publication statusPublished - 2000

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B-Cell Leukemia
Peripheral T-Cell Lymphoma
Hairy Cell Leukemia
Cutaneous T-Cell Lymphoma
T-Cell Lymphoma
B-Cell Lymphoma
Non-Hodgkin's Lymphoma
Skin
Circulating Neoplastic Cells
Neoplastic Processes
Lymphocytosis
Mycosis Fungoides
Virus Diseases
Southern Blotting
Skin Diseases
B-Lymphocytes
Bone Marrow
T-Lymphocytes
Biopsy

Keywords

  • Hairy cell leukemia
  • Peripheral T-cell lymphoma
  • Semi-nested PCR
  • Southern blot analysis

ASJC Scopus subject areas

  • Hematology

Cite this

Co-existence of cutaneous T-cell lymphoma and B hairy cell leukemia. / Paolini, Rossella; Poletti, Alessandro; Ramazzina, Emilio; Menin, Chiara; Santacatterina, Maria; Montagna, Marco; Bonaldi, Laura; Del Mistro, Annarosa; Zamboni, Sergio; D'Andrea, Emma.

In: American Journal of Hematology, Vol. 64, No. 3, 2000, p. 197-202.

Research output: Contribution to journalArticle

Paolini, Rossella ; Poletti, Alessandro ; Ramazzina, Emilio ; Menin, Chiara ; Santacatterina, Maria ; Montagna, Marco ; Bonaldi, Laura ; Del Mistro, Annarosa ; Zamboni, Sergio ; D'Andrea, Emma. / Co-existence of cutaneous T-cell lymphoma and B hairy cell leukemia. In: American Journal of Hematology. 2000 ; Vol. 64, No. 3. pp. 197-202.
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