Abstract
In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.
| Original language | English |
|---|---|
| Pages (from-to) | 361-365 |
| Number of pages | 5 |
| Journal | European Journal of Haematology |
| Volume | 72 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2004 |
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Keywords
- Chronic lymphocytic leukemia
- Chronic myeloid leukemia
- Imatinib
- Megakaryoblast
- Philadelphia chromosome
ASJC Scopus subject areas
- Hematology
Cite this
Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. / Colla, Simona; Sammarelli, Gabriella; Crugnola, Monica; Ascani, Stefano; Sabbatini, Elena; Bonomini, Sabrina; Hojden, Magda; Craviotto, Luisa; De Celis, Isabel; Morandi, Francesca; Caramatti, Cecilia; Rizzoli, Vittorio; Giuliani, Nicola.
In: European Journal of Haematology, Vol. 72, No. 5, 05.2004, p. 361-365.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia
AU - Colla, Simona
AU - Sammarelli, Gabriella
AU - Crugnola, Monica
AU - Ascani, Stefano
AU - Sabbatini, Elena
AU - Bonomini, Sabrina
AU - Hojden, Magda
AU - Craviotto, Luisa
AU - De Celis, Isabel
AU - Morandi, Francesca
AU - Caramatti, Cecilia
AU - Rizzoli, Vittorio
AU - Giuliani, Nicola
PY - 2004/5
Y1 - 2004/5
N2 - In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.
AB - In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.
KW - Chronic lymphocytic leukemia
KW - Chronic myeloid leukemia
KW - Imatinib
KW - Megakaryoblast
KW - Philadelphia chromosome
UR - http://www.scopus.com/inward/record.url?scp=11144354577&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=11144354577&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0609.2004.00222.x
DO - 10.1111/j.1600-0609.2004.00222.x
M3 - Article
C2 - 15059073
AN - SCOPUS:11144354577
VL - 72
SP - 361
EP - 365
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 5
ER -