Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Simona Colla; Gabriella Sammarelli; Monica Crugnola; Stefano Ascani; Elena Sabbatini; Sabrina Bonomini; Magda Hojden; Luisa Craviotto; Isabel De Celis; Francesca Morandi; Cecilia Caramatti; Vittorio Rizzoli; Nicola Giuliani

doi:10.1111/j.1600-0609.2004.00222.x

Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Simona Colla, Gabriella Sammarelli, Monica Crugnola, Stefano Ascani, Elena Sabbatini, Sabrina Bonomini, Magda Hojden, Luisa Craviotto, Isabel De Celis, Francesca Morandi, Cecilia Caramatti, Vittorio Rizzoli, Nicola Giuliani

Arcispedale Santa Maria Nuova

Research output: Contribution to journal › Article

Abstract

In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.

Original language	English
Pages (from-to)	361-365
Number of pages	5
Journal	European Journal of Haematology
Volume	72
Issue number	5
DOIs	https://doi.org/10.1111/j.1600-0609.2004.00222.x
Publication status	Published - May 2004

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Keywords

Chronic lymphocytic leukemia
Chronic myeloid leukemia
Imatinib
Megakaryoblast
Philadelphia chromosome

ASJC Scopus subject areas

Hematology

Cite this

Colla, S., Sammarelli, G., Crugnola, M., Ascani, S., Sabbatini, E., Bonomini, S., Hojden, M., Craviotto, L., De Celis, I., Morandi, F., Caramatti, C., Rizzoli, V., & Giuliani, N. (2004). Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. European Journal of Haematology, 72(5), 361-365. https://doi.org/10.1111/j.1600-0609.2004.00222.x

Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. / Colla, Simona; Sammarelli, Gabriella; Crugnola, Monica; Ascani, Stefano; Sabbatini, Elena; Bonomini, Sabrina; Hojden, Magda; Craviotto, Luisa; De Celis, Isabel; Morandi, Francesca; Caramatti, Cecilia; Rizzoli, Vittorio; Giuliani, Nicola.

In: European Journal of Haematology, Vol. 72, No. 5, 05.2004, p. 361-365.

Research output: Contribution to journal › Article

Colla, S, Sammarelli, G, Crugnola, M, Ascani, S, Sabbatini, E, Bonomini, S, Hojden, M, Craviotto, L, De Celis, I, Morandi, F, Caramatti, C, Rizzoli, V & Giuliani, N 2004, 'Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia', European Journal of Haematology, vol. 72, no. 5, pp. 361-365. https://doi.org/10.1111/j.1600-0609.2004.00222.x

Colla, Simona ; Sammarelli, Gabriella ; Crugnola, Monica ; Ascani, Stefano ; Sabbatini, Elena ; Bonomini, Sabrina ; Hojden, Magda ; Craviotto, Luisa ; De Celis, Isabel ; Morandi, Francesca ; Caramatti, Cecilia ; Rizzoli, Vittorio ; Giuliani, Nicola. / Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. In: European Journal of Haematology. 2004 ; Vol. 72, No. 5. pp. 361-365.

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abstract = "In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.",

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AU - Sabbatini, Elena

AU - Bonomini, Sabrina

AU - Hojden, Magda

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AU - De Celis, Isabel

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10.1111/j.1600-0609.2004.00222.x