Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia

Simona Colla, Gabriella Sammarelli, Monica Crugnola, Stefano Ascani, Elena Sabbatini, Sabrina Bonomini, Magda Hojden, Luisa Craviotto, Isabel De Celis, Francesca Morandi, Cecilia Caramatti, Vittorio Rizzoli, Nicola Giuliani

Research output: Contribution to journalArticle

Abstract

In this study, we describe an extremely rare case of co-existence of a Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.

Original languageEnglish
Pages (from-to)361-365
Number of pages5
JournalEuropean Journal of Haematology
Volume72
Issue number5
DOIs
Publication statusPublished - May 2004

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Keywords

  • Chronic lymphocytic leukemia
  • Chronic myeloid leukemia
  • Imatinib
  • Megakaryoblast
  • Philadelphia chromosome

ASJC Scopus subject areas

  • Hematology

Cite this

Colla, S., Sammarelli, G., Crugnola, M., Ascani, S., Sabbatini, E., Bonomini, S., Hojden, M., Craviotto, L., De Celis, I., Morandi, F., Caramatti, C., Rizzoli, V., & Giuliani, N. (2004). Co-existence of Philadelphia chromosome positive acute megakaryoblastic and B-lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia. European Journal of Haematology, 72(5), 361-365. https://doi.org/10.1111/j.1600-0609.2004.00222.x