CO sniffing through heme-based sensor proteins

Paolo Ascenzi; Alessio Bocedi; Livia Leoni; Paolo Visca; Elisabetta Zennaro; Mario Milani; Martino Bolognesi

doi:10.1080/10258140412331286937

CO sniffing through heme-based sensor proteins

Paolo Ascenzi, Alessio Bocedi, Livia Leoni, Paolo Visca, Elisabetta Zennaro, Mario Milani, Martino Bolognesi

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article

Abstract

O₂, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O₂ respiration, denitrification, N₂ fixation, and methanogenesis. Over the last decade, O₂, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.

Original language	English
Pages (from-to)	309-315
Number of pages	7
Journal	IUBMB Life
Volume	56
Issue number	6
DOIs	https://doi.org/10.1080/10258140412331286937
Publication status	Published - Jun 2004

Keywords

CO sensing
CO signal transduction
CooA
NPAS2

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Genetics
Cell Biology

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Ascenzi, P., Bocedi, A., Leoni, L., Visca, P., Zennaro, E., Milani, M., & Bolognesi, M. (2004). CO sniffing through heme-based sensor proteins. IUBMB Life, 56(6), 309-315. https://doi.org/10.1080/10258140412331286937

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AU - Milani, Mario

AU - Bolognesi, Martino

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