TY - JOUR
T1 - CO sniffing through heme-based sensor proteins
AU - Ascenzi, Paolo
AU - Bocedi, Alessio
AU - Leoni, Livia
AU - Visca, Paolo
AU - Zennaro, Elisabetta
AU - Milani, Mario
AU - Bolognesi, Martino
PY - 2004/6
Y1 - 2004/6
N2 - O2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O2 respiration, denitrification, N2 fixation, and methanogenesis. Over the last decade, O2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.
AB - O2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O2 respiration, denitrification, N2 fixation, and methanogenesis. Over the last decade, O2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.
KW - CO sensing
KW - CO signal transduction
KW - CooA
KW - NPAS2
UR - http://www.scopus.com/inward/record.url?scp=7044226454&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=7044226454&partnerID=8YFLogxK
U2 - 10.1080/10258140412331286937
DO - 10.1080/10258140412331286937
M3 - Article
C2 - 15370879
AN - SCOPUS:7044226454
VL - 56
SP - 309
EP - 315
JO - IUBMB Life
JF - IUBMB Life
SN - 1521-6543
IS - 6
ER -