CO sniffing through heme-based sensor proteins

Paolo Ascenzi, Alessio Bocedi, Livia Leoni, Paolo Visca, Elisabetta Zennaro, Mario Milani, Martino Bolognesi

Research output: Contribution to journalArticlepeer-review


O2, NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O2 respiration, denitrification, N2 fixation, and methanogenesis. Over the last decade, O2, NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.

Original languageEnglish
Pages (from-to)309-315
Number of pages7
JournalIUBMB Life
Issue number6
Publication statusPublished - Jun 2004


  • CO sensing
  • CO signal transduction
  • CooA
  • NPAS2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology


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