Coagulation and fibrinolysis changes in normal pregnancy increased levels of procoagulants and reduced levels of inhibitors during pregnancy induce a hypercoagulable state, combined with a reactive fibrinolysis

Federico Cerneca, Giuseppe Ricci, Roberto Simeone, Monica Malisano, Salvatore Alberico, Seconde Guaschino

Research output: Contribution to journalArticle

Abstract

Objective: To establish the physiologic changes in the coagulation and fibrinolytic systems during normal pregnancy and puerperium. Study Design: One hundred and seventeen normal pregnant women were investigated in a longitudinal study involving five measurements: blood samples were collected at 10, 20, 30, 36 weeks and on the second day puerperium and were assayed for prothrombin time (PT expressed in INR), activated partial thromboplastin time (PLY), fibrinogen (FBG), antithrombin III activity (AT III), protein C activity (PC), protein S activity (PS), prothrombin fragments 1+2 (F1 +2), type 1 plasminogen activator inhibitor activity (PAI) and tissue-plasminogen activator antigen (t-PA). Student t-test, One Way Analysis of Variance (ANOVA) and Bonferroni test were used for statistical analysis. P

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume73
Issue number1
DOIs
Publication statusPublished - May 1997

Keywords

  • Coagulation
  • Fibrinolysis
  • Pregnancy
  • Puerperium

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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