Coarse vs. fine needle aspiration biopsy for the assessment of diffuse liver disease from hepatitis C virus-related chronic hepatitis

Enrico Brunetti, Enrico Silini, Angela Pistorio, Alessandra Cavallero, Anna Marangio, Raffaele Bruno, Carlo Filice

Research output: Contribution to journalArticle


Background/Aims: Liver biopsy is crucial in defining natural history and therapeutic choices in chronic hepatitis C and it is usually performed with coarse (>1 mm) needles (CN). As fine needles (FN) do not require anaesthesia, are used over a wider range of coagulation values and allow multiple passes, we compared the diagnostic yield of FN vs. CN biopsies. Methods: Paired samples obtained with FN (0.8 mm) and CN (1.2 mm) on 149 consecutive outpatients from a tertiary care institution were evaluated prospectively. Histologic variables were quantitatively scored. Sensitivity, specificity, positive predictive value, negative predictive value and positive likelihood ratio were calculated as measures of diagnostic ability assuming CN as reference. Results: FN biopsy was adequate in 83 cases, CN in 140 cases (P

Original languageEnglish
Pages (from-to)501-506
Number of pages6
JournalJournal of Hepatology
Issue number3
Publication statusPublished - Mar 2004



  • Chronic hepatitis
  • Liver biopsy
  • Liver histology
  • Microhistology

ASJC Scopus subject areas

  • Gastroenterology

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