Cobalamin deficiency: Clinical picture and radiological findings

Chiara Briani, Chiara Dalla Torre, Valentina Citton, Renzo Manara, Sara Pompanin, Gianni Binotto, Fausto Adami

Research output: Contribution to journalArticle

Abstract

Vitamin B12 deficiency causes a wide range of hematological, gastrointestinal, psychiatric and neurological disorders. Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe anemia, such as angor, dyspnea on exertion, fatigue or symptoms related to congestive heart failure, such as ankle edema, orthopnea and nocturia. Neuropsychiatric symptoms may precede hematologic signs and are represented by myelopathy, neuropathy, dementia and, less often, optic nerve atrophy. The spinal cord manifestation, subacute combined degeneration (SCD), is characterized by symmetric dysesthesia, disturbance of position sense and spastic paraparesis or tetraparesis. The most consistent MRI finding is a symmetrical abnormally increased T2 signal intensity confined to posterior or posterior and lateral columns in the cervical and thoracic spinal cord. Isolated peripheral neuropathy is less frequent, but likely overlooked. Vitamin B12 deficiency has been correlated negatively with cognitive functioning in healthy elderly subjects. Symptoms include slow mentation, memory impairment, attention deficits and dementia. Optic neuropathy occurs occasionally in adult patient. It is characterized by symmetric, painless and progressive visual loss. Parenteral replacement therapy should be started soon after the vitamin deficiency has been established.

Original languageEnglish
Pages (from-to)4521-4539
Number of pages19
JournalNutrients
Volume5
Issue number11
DOIs
Publication statusPublished - Nov 15 2013

Fingerprint

Vitamin B 12 Deficiency
vitamin B12
Vitamin B 12
signs and symptoms (animals and humans)
peripheral nervous system diseases
Dementia
Subacute Combined Degeneration
Spastic Paraparesis
Nocturia
Avitaminosis
Optic Atrophy
Proprioception
Optic Nerve Diseases
Erythrocyte Indices
dementia
Paresthesia
Spinal Cord Diseases
Peripheral Nervous System Diseases
Optic Nerve
optics

Keywords

  • Cobalamin
  • Neuroimaging
  • Neuropathy
  • Subacute combined degeneration
  • Vitamin B12

ASJC Scopus subject areas

  • Food Science

Cite this

Briani, C., Torre, C. D., Citton, V., Manara, R., Pompanin, S., Binotto, G., & Adami, F. (2013). Cobalamin deficiency: Clinical picture and radiological findings. Nutrients, 5(11), 4521-4539. https://doi.org/10.3390/nu5114521

Cobalamin deficiency : Clinical picture and radiological findings. / Briani, Chiara; Torre, Chiara Dalla; Citton, Valentina; Manara, Renzo; Pompanin, Sara; Binotto, Gianni; Adami, Fausto.

In: Nutrients, Vol. 5, No. 11, 15.11.2013, p. 4521-4539.

Research output: Contribution to journalArticle

Briani, C, Torre, CD, Citton, V, Manara, R, Pompanin, S, Binotto, G & Adami, F 2013, 'Cobalamin deficiency: Clinical picture and radiological findings', Nutrients, vol. 5, no. 11, pp. 4521-4539. https://doi.org/10.3390/nu5114521
Briani C, Torre CD, Citton V, Manara R, Pompanin S, Binotto G et al. Cobalamin deficiency: Clinical picture and radiological findings. Nutrients. 2013 Nov 15;5(11):4521-4539. https://doi.org/10.3390/nu5114521
Briani, Chiara ; Torre, Chiara Dalla ; Citton, Valentina ; Manara, Renzo ; Pompanin, Sara ; Binotto, Gianni ; Adami, Fausto. / Cobalamin deficiency : Clinical picture and radiological findings. In: Nutrients. 2013 ; Vol. 5, No. 11. pp. 4521-4539.
@article{ac7d704a67c14ec5a547bab20e026d33,
title = "Cobalamin deficiency: Clinical picture and radiological findings",
abstract = "Vitamin B12 deficiency causes a wide range of hematological, gastrointestinal, psychiatric and neurological disorders. Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe anemia, such as angor, dyspnea on exertion, fatigue or symptoms related to congestive heart failure, such as ankle edema, orthopnea and nocturia. Neuropsychiatric symptoms may precede hematologic signs and are represented by myelopathy, neuropathy, dementia and, less often, optic nerve atrophy. The spinal cord manifestation, subacute combined degeneration (SCD), is characterized by symmetric dysesthesia, disturbance of position sense and spastic paraparesis or tetraparesis. The most consistent MRI finding is a symmetrical abnormally increased T2 signal intensity confined to posterior or posterior and lateral columns in the cervical and thoracic spinal cord. Isolated peripheral neuropathy is less frequent, but likely overlooked. Vitamin B12 deficiency has been correlated negatively with cognitive functioning in healthy elderly subjects. Symptoms include slow mentation, memory impairment, attention deficits and dementia. Optic neuropathy occurs occasionally in adult patient. It is characterized by symmetric, painless and progressive visual loss. Parenteral replacement therapy should be started soon after the vitamin deficiency has been established.",
keywords = "Cobalamin, Neuroimaging, Neuropathy, Subacute combined degeneration, Vitamin B12",
author = "Chiara Briani and Torre, {Chiara Dalla} and Valentina Citton and Renzo Manara and Sara Pompanin and Gianni Binotto and Fausto Adami",
year = "2013",
month = "11",
day = "15",
doi = "10.3390/nu5114521",
language = "English",
volume = "5",
pages = "4521--4539",
journal = "Nutrients",
issn = "2072-6643",
publisher = "NLM (Medline)",
number = "11",

}

TY - JOUR

T1 - Cobalamin deficiency

T2 - Clinical picture and radiological findings

AU - Briani, Chiara

AU - Torre, Chiara Dalla

AU - Citton, Valentina

AU - Manara, Renzo

AU - Pompanin, Sara

AU - Binotto, Gianni

AU - Adami, Fausto

PY - 2013/11/15

Y1 - 2013/11/15

N2 - Vitamin B12 deficiency causes a wide range of hematological, gastrointestinal, psychiatric and neurological disorders. Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe anemia, such as angor, dyspnea on exertion, fatigue or symptoms related to congestive heart failure, such as ankle edema, orthopnea and nocturia. Neuropsychiatric symptoms may precede hematologic signs and are represented by myelopathy, neuropathy, dementia and, less often, optic nerve atrophy. The spinal cord manifestation, subacute combined degeneration (SCD), is characterized by symmetric dysesthesia, disturbance of position sense and spastic paraparesis or tetraparesis. The most consistent MRI finding is a symmetrical abnormally increased T2 signal intensity confined to posterior or posterior and lateral columns in the cervical and thoracic spinal cord. Isolated peripheral neuropathy is less frequent, but likely overlooked. Vitamin B12 deficiency has been correlated negatively with cognitive functioning in healthy elderly subjects. Symptoms include slow mentation, memory impairment, attention deficits and dementia. Optic neuropathy occurs occasionally in adult patient. It is characterized by symmetric, painless and progressive visual loss. Parenteral replacement therapy should be started soon after the vitamin deficiency has been established.

AB - Vitamin B12 deficiency causes a wide range of hematological, gastrointestinal, psychiatric and neurological disorders. Hematological presentation of cobalamin deficiency ranges from the incidental increase of mean corpuscular volume and neutrophil hypersegmentation to symptoms due to severe anemia, such as angor, dyspnea on exertion, fatigue or symptoms related to congestive heart failure, such as ankle edema, orthopnea and nocturia. Neuropsychiatric symptoms may precede hematologic signs and are represented by myelopathy, neuropathy, dementia and, less often, optic nerve atrophy. The spinal cord manifestation, subacute combined degeneration (SCD), is characterized by symmetric dysesthesia, disturbance of position sense and spastic paraparesis or tetraparesis. The most consistent MRI finding is a symmetrical abnormally increased T2 signal intensity confined to posterior or posterior and lateral columns in the cervical and thoracic spinal cord. Isolated peripheral neuropathy is less frequent, but likely overlooked. Vitamin B12 deficiency has been correlated negatively with cognitive functioning in healthy elderly subjects. Symptoms include slow mentation, memory impairment, attention deficits and dementia. Optic neuropathy occurs occasionally in adult patient. It is characterized by symmetric, painless and progressive visual loss. Parenteral replacement therapy should be started soon after the vitamin deficiency has been established.

KW - Cobalamin

KW - Neuroimaging

KW - Neuropathy

KW - Subacute combined degeneration

KW - Vitamin B12

UR - http://www.scopus.com/inward/record.url?scp=84887743847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887743847&partnerID=8YFLogxK

U2 - 10.3390/nu5114521

DO - 10.3390/nu5114521

M3 - Article

C2 - 24248213

AN - SCOPUS:84887743847

VL - 5

SP - 4521

EP - 4539

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 11

ER -