Abstract
We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertical spectrometer, and the volume of cerebrospinal fluid (CSF) in this part of the vertebral canal was calculated. The findings of the present study demonstrate that: (i) there was a significant decrease in cervical tract CSF volume regardless of the way in which the vitamin deficiency was induced; (ii) this volume normalized in the totally gastrectomized rats after chronic Cbl treatment; (iii) no blood-brain or blood-CSF barrier lesions were found in Cbl-D rats, using either MRI with a paramagnetic contrast agent or calculating the albumin CSF/serum concentration quotient. Cbl deficiency decreases CSF volume in the cervical tract of the vertebral canal of the rat, without apparently impairing the blood-brain barrier.
| Original language | English |
|---|---|
| Pages (from-to) | 202-205 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 440 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Aug 8 2008 |
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Keywords
- Cerebrospinal fluid
- Cobalamin
- Cobalamin deficiency
- Magnetic resonance imaging
- Total gastrectomy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Cobalamin deficiency-induced changes in magnetic resonance imaging of cerebrospinal fluid volume in the cervical tract in the rat. / Veber, Daniela; Mutti, Elena; Sironi, Luigi; Guerrini, Uliano; Gianazza, Elisabetta; Scalabrino, Giuseppe.
In: Neuroscience Letters, Vol. 440, No. 3, 08.08.2008, p. 202-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cobalamin deficiency-induced changes in magnetic resonance imaging of cerebrospinal fluid volume in the cervical tract in the rat
AU - Veber, Daniela
AU - Mutti, Elena
AU - Sironi, Luigi
AU - Guerrini, Uliano
AU - Gianazza, Elisabetta
AU - Scalabrino, Giuseppe
PY - 2008/8/8
Y1 - 2008/8/8
N2 - We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertical spectrometer, and the volume of cerebrospinal fluid (CSF) in this part of the vertebral canal was calculated. The findings of the present study demonstrate that: (i) there was a significant decrease in cervical tract CSF volume regardless of the way in which the vitamin deficiency was induced; (ii) this volume normalized in the totally gastrectomized rats after chronic Cbl treatment; (iii) no blood-brain or blood-CSF barrier lesions were found in Cbl-D rats, using either MRI with a paramagnetic contrast agent or calculating the albumin CSF/serum concentration quotient. Cbl deficiency decreases CSF volume in the cervical tract of the vertebral canal of the rat, without apparently impairing the blood-brain barrier.
AB - We wanted to verify the magnetic resonance imaging (MRI) abnormalities that occur in the central nervous system (CNS) of cobalamin-deficient (Cbl-D) rats. The rats were made Cbl-D by means of total gastrectomy or feeding a Cbl-D diet. MR images of the cervical tract of the vertebral canal were recorded using a vertical spectrometer, and the volume of cerebrospinal fluid (CSF) in this part of the vertebral canal was calculated. The findings of the present study demonstrate that: (i) there was a significant decrease in cervical tract CSF volume regardless of the way in which the vitamin deficiency was induced; (ii) this volume normalized in the totally gastrectomized rats after chronic Cbl treatment; (iii) no blood-brain or blood-CSF barrier lesions were found in Cbl-D rats, using either MRI with a paramagnetic contrast agent or calculating the albumin CSF/serum concentration quotient. Cbl deficiency decreases CSF volume in the cervical tract of the vertebral canal of the rat, without apparently impairing the blood-brain barrier.
KW - Cerebrospinal fluid
KW - Cobalamin
KW - Cobalamin deficiency
KW - Magnetic resonance imaging
KW - Total gastrectomy
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UR - http://www.scopus.com/inward/citedby.url?scp=45849101675&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2008.05.079
DO - 10.1016/j.neulet.2008.05.079
M3 - Article
C2 - 18571320
AN - SCOPUS:45849101675
VL - 440
SP - 202
EP - 205
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -