Cobalt myocardiopathy. A critical review of literature

P. Seghizzi, F. D'Adda, D. Borleri, F. Barbic, G. Mosconi

Research output: Contribution to journalArticlepeer-review


Cobalt is regarded as being responsible for a form of myocardiopathy whose pathogenisis and clinical description must still find a specific place in the range of congestive myocardiopathies. In spite of this, epidemiological studies are not sufficient to prove the role of cobalt in inducing myocardiopathy in hard metal workers. This critical review intends to evaluate if hard metal exposure may induce toxic effects on the heart. In this context, the literature considered ranges from pioneer reports on 'beer drinkers' to the more recent papers concerning cases of patients occupationally exposed; subjects who, after a surgical operation died of fulminant heart failure and, lastly, hard metal workers who were examined for their cardiac function. Various pathogenetic mechanisms related to possible cardiac effects in hard metal workers have been analyzed. The most likely should be the inhibition of cellular respiration due to inhibition of the mitocondrial dehydrogenase.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalScience of the Total Environment
Issue number1-3
Publication statusPublished - Jun 30 1994


  • Beer drinkers
  • Cobalt myocardiopathy
  • Hard metal workers
  • Pathogenesis
  • Review

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry


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