Abstract
Cocaine abuse in pregnancy has been evaluated through toxicological analysis of hair from 123 pathological new-borns admitted an in intensive care division. The new-borns were affected with malformations, low gestational age, low birth weight, respiratory distress. A control group of 39 healthy new-borns was also analysed. Hair samples (about 50 mg) were enzymatically digested and directly analysed by RIA. Samples positive to the preliminary screening were extracted by SPE columns and injected in GC/MS. Results obtained showed 3 positive samples (2.4%). All cocaine babies had low gestational age, low birth weight, two of them showed heart malformation, one kidney malformation and one genital malformation. None of the control new-born resulted positive for cocaine. These results show a worrying trend of cocaine diffusion in the Italian population.
| Original language | English |
|---|---|
| Pages (from-to) | 1909-1915 |
| Number of pages | 7 |
| Journal | Life Sciences |
| Volume | 59 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - Oct 25 1996 |
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Keywords
- cocaine abuse
- foetal malformations
- hair analysis
- pregnancy
ASJC Scopus subject areas
- Pharmacology
Cite this
Cocaine abuse in pregnancy : Its evaluation through hair analysis of pathological new-borns. / Strano-Rossi, Sabina; Chiarotti, Marcello; Fiori, Angelo; Auriti, Cinzia; Seganti, Giulio.
In: Life Sciences, Vol. 59, No. 22, 25.10.1996, p. 1909-1915.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cocaine abuse in pregnancy
T2 - Its evaluation through hair analysis of pathological new-borns
AU - Strano-Rossi, Sabina
AU - Chiarotti, Marcello
AU - Fiori, Angelo
AU - Auriti, Cinzia
AU - Seganti, Giulio
PY - 1996/10/25
Y1 - 1996/10/25
N2 - Cocaine abuse in pregnancy has been evaluated through toxicological analysis of hair from 123 pathological new-borns admitted an in intensive care division. The new-borns were affected with malformations, low gestational age, low birth weight, respiratory distress. A control group of 39 healthy new-borns was also analysed. Hair samples (about 50 mg) were enzymatically digested and directly analysed by RIA. Samples positive to the preliminary screening were extracted by SPE columns and injected in GC/MS. Results obtained showed 3 positive samples (2.4%). All cocaine babies had low gestational age, low birth weight, two of them showed heart malformation, one kidney malformation and one genital malformation. None of the control new-born resulted positive for cocaine. These results show a worrying trend of cocaine diffusion in the Italian population.
AB - Cocaine abuse in pregnancy has been evaluated through toxicological analysis of hair from 123 pathological new-borns admitted an in intensive care division. The new-borns were affected with malformations, low gestational age, low birth weight, respiratory distress. A control group of 39 healthy new-borns was also analysed. Hair samples (about 50 mg) were enzymatically digested and directly analysed by RIA. Samples positive to the preliminary screening were extracted by SPE columns and injected in GC/MS. Results obtained showed 3 positive samples (2.4%). All cocaine babies had low gestational age, low birth weight, two of them showed heart malformation, one kidney malformation and one genital malformation. None of the control new-born resulted positive for cocaine. These results show a worrying trend of cocaine diffusion in the Italian population.
KW - cocaine abuse
KW - foetal malformations
KW - hair analysis
KW - pregnancy
UR - http://www.scopus.com/inward/record.url?scp=0030601743&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030601743&partnerID=8YFLogxK
U2 - 10.1016/S0024-3205(96)00538-3
DO - 10.1016/S0024-3205(96)00538-3
M3 - Article
C2 - 8950288
AN - SCOPUS:0030601743
VL - 59
SP - 1909
EP - 1915
JO - Life Sciences
JF - Life Sciences
SN - 0024-3205
IS - 22
ER -