Cocaine dependence and stroke

Pathogenesis and management

Antonio Siniscalchi, Antonello Bonci, Nicola Biagio Mercuri, Antonia De Siena, Giovambattista De Sarro, Giovanni Malferrari, Marco Diana, Luca Gallelli

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Cocaine abuse remains a devastating medical problem for our society. Current concepts suggest that both hemorrhagic and ischemic stroke, particularly in young people, can result as a consequence of cocaine exposure. We provide an analysis of mechanisms of injury and a discussion of the pharmacological management of stroke following cocaine use. Preclinical research suggests that the cause of cocaine-mediated stroke is multifactorial and involves vasospasm, changes in cerebral vasculature, and platelet aggregation. We suggest that drugs able to induce vasospastic, thrombogenic, or neurotoxic effects of cocaine could be suitable as therapeutic agents. In contrast caution should be exerted when using anti-platelet and thrombolytic agents in cocaine users with stroke.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalCurrent Neurovascular Research
Volume12
Issue number2
Publication statusPublished - 2015

Fingerprint

Cocaine-Related Disorders
Cocaine
Stroke
Fibrinolytic Agents
Platelet Aggregation
Blood Platelets
Pharmacology
Wounds and Injuries
Research
Pharmaceutical Preparations

Keywords

  • Antineurotoxic agents
  • Antithrombogenic agents
  • Antivasospastic agents
  • Cocaine
  • Hemorrhagic stroke
  • Ischemic stroke

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Siniscalchi, A., Bonci, A., Mercuri, N. B., De Siena, A., De Sarro, G., Malferrari, G., ... Gallelli, L. (2015). Cocaine dependence and stroke: Pathogenesis and management. Current Neurovascular Research, 12(2), 163-172.

Cocaine dependence and stroke : Pathogenesis and management. / Siniscalchi, Antonio; Bonci, Antonello; Mercuri, Nicola Biagio; De Siena, Antonia; De Sarro, Giovambattista; Malferrari, Giovanni; Diana, Marco; Gallelli, Luca.

In: Current Neurovascular Research, Vol. 12, No. 2, 2015, p. 163-172.

Research output: Contribution to journalArticle

Siniscalchi, A, Bonci, A, Mercuri, NB, De Siena, A, De Sarro, G, Malferrari, G, Diana, M & Gallelli, L 2015, 'Cocaine dependence and stroke: Pathogenesis and management', Current Neurovascular Research, vol. 12, no. 2, pp. 163-172.
Siniscalchi A, Bonci A, Mercuri NB, De Siena A, De Sarro G, Malferrari G et al. Cocaine dependence and stroke: Pathogenesis and management. Current Neurovascular Research. 2015;12(2):163-172.
Siniscalchi, Antonio ; Bonci, Antonello ; Mercuri, Nicola Biagio ; De Siena, Antonia ; De Sarro, Giovambattista ; Malferrari, Giovanni ; Diana, Marco ; Gallelli, Luca. / Cocaine dependence and stroke : Pathogenesis and management. In: Current Neurovascular Research. 2015 ; Vol. 12, No. 2. pp. 163-172.
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