Coccoid and spiral Helicobacter pylori differ in their abilities to adhere to gastric epithelial cells and induce interleukin-8 secretion

S. P. Cole, D. Cirillo, M. F. Kagnoff, D. G. Guiney, L. Eckmann

Research output: Contribution to journalArticle


Helicobacter pylori exists as an actively dividing spiral form and a nonculturable, but viable, metabolizing coccoid form. Both forms are present in the stomach, but their relative pathophysiologic significances are unknown. Here we show that the coccoid form of H. pylori, in contrast to the spiral form, binds poorly to gastric epithelial cells and induces little, if any, interleukin-8 secretion by these cells.

Original languageEnglish
Pages (from-to)843-846
Number of pages4
JournalInfection and Immunity
Issue number2
Publication statusPublished - 1997


ASJC Scopus subject areas

  • Immunology

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