Cochlear injury and adaptive plasticity of the auditory cortex

Anna Rita Fetoni, Diana Troiani, Laura Petrosini, Gaetano Paludetti

Research output: Contribution to journalArticle

Abstract

Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex. Studies centered on such changes have revealed several mechanisms that operate in the context of sensory disruption after insult (noise trauma, drug-, or age-related injury). The oxidative stress is central to current theories of induced sensory-neural hearing loss and aging, and interventions to attenuate the hearing loss are based on antioxidant agent. The present review addresses the recent literature on the alterations in hair cells and spiral ganglion neurons due to noise-induced oxidative stress in the cochlea, as well on the impact of cochlear damage on the auditory cortex neurons. The emerging image emphasizes that noise-induced deafferentation and upward spread of cochlear damage is associated with the altered dendritic architecture of auditory pyramidal neurons. The cortical modifications may be reversed by treatment with antioxidants counteracting the cochlear redox imbalance. These findings open new therapeutic approaches to treat the functional consequences of the cortical reorganization following cochlear damage.

Original languageEnglish
Article number8
JournalFrontiers in Aging Neuroscience
Volume7
Issue numberFEB
DOIs
Publication statusPublished - 2015

Fingerprint

Auditory Cortex
Cochlea
Noise
Wounds and Injuries
Hearing Loss
Oxidative Stress
Antioxidants
Spiral Ganglion
Neurons
Pyramidal Cells
Brain Stem
Oxidation-Reduction
Pharmaceutical Preparations

Keywords

  • Auditory cortex
  • Noise-induced hearing loss
  • Oxidative stress
  • Presbycusis
  • Pyramidal neurons

ASJC Scopus subject areas

  • Ageing
  • Cognitive Neuroscience

Cite this

Cochlear injury and adaptive plasticity of the auditory cortex. / Fetoni, Anna Rita; Troiani, Diana; Petrosini, Laura; Paludetti, Gaetano.

In: Frontiers in Aging Neuroscience, Vol. 7, No. FEB, 8, 2015.

Research output: Contribution to journalArticle

Fetoni, Anna Rita ; Troiani, Diana ; Petrosini, Laura ; Paludetti, Gaetano. / Cochlear injury and adaptive plasticity of the auditory cortex. In: Frontiers in Aging Neuroscience. 2015 ; Vol. 7, No. FEB.
@article{6ed5142e81e147ad9c27e12ad19efdce,
title = "Cochlear injury and adaptive plasticity of the auditory cortex",
abstract = "Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex. Studies centered on such changes have revealed several mechanisms that operate in the context of sensory disruption after insult (noise trauma, drug-, or age-related injury). The oxidative stress is central to current theories of induced sensory-neural hearing loss and aging, and interventions to attenuate the hearing loss are based on antioxidant agent. The present review addresses the recent literature on the alterations in hair cells and spiral ganglion neurons due to noise-induced oxidative stress in the cochlea, as well on the impact of cochlear damage on the auditory cortex neurons. The emerging image emphasizes that noise-induced deafferentation and upward spread of cochlear damage is associated with the altered dendritic architecture of auditory pyramidal neurons. The cortical modifications may be reversed by treatment with antioxidants counteracting the cochlear redox imbalance. These findings open new therapeutic approaches to treat the functional consequences of the cortical reorganization following cochlear damage.",
keywords = "Auditory cortex, Noise-induced hearing loss, Oxidative stress, Presbycusis, Pyramidal neurons",
author = "Fetoni, {Anna Rita} and Diana Troiani and Laura Petrosini and Gaetano Paludetti",
year = "2015",
doi = "10.3389/fnagi.2015.00008",
language = "English",
volume = "7",
journal = "Frontiers in Aging Neuroscience",
issn = "1663-4365",
publisher = "Frontiers Research Foundation",
number = "FEB",

}

TY - JOUR

T1 - Cochlear injury and adaptive plasticity of the auditory cortex

AU - Fetoni, Anna Rita

AU - Troiani, Diana

AU - Petrosini, Laura

AU - Paludetti, Gaetano

PY - 2015

Y1 - 2015

N2 - Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex. Studies centered on such changes have revealed several mechanisms that operate in the context of sensory disruption after insult (noise trauma, drug-, or age-related injury). The oxidative stress is central to current theories of induced sensory-neural hearing loss and aging, and interventions to attenuate the hearing loss are based on antioxidant agent. The present review addresses the recent literature on the alterations in hair cells and spiral ganglion neurons due to noise-induced oxidative stress in the cochlea, as well on the impact of cochlear damage on the auditory cortex neurons. The emerging image emphasizes that noise-induced deafferentation and upward spread of cochlear damage is associated with the altered dendritic architecture of auditory pyramidal neurons. The cortical modifications may be reversed by treatment with antioxidants counteracting the cochlear redox imbalance. These findings open new therapeutic approaches to treat the functional consequences of the cortical reorganization following cochlear damage.

AB - Growing evidence suggests that cochlear stressors as noise exposure and aging can induce homeostatic/maladaptive changes in the central auditory system from the brainstem to the cortex. Studies centered on such changes have revealed several mechanisms that operate in the context of sensory disruption after insult (noise trauma, drug-, or age-related injury). The oxidative stress is central to current theories of induced sensory-neural hearing loss and aging, and interventions to attenuate the hearing loss are based on antioxidant agent. The present review addresses the recent literature on the alterations in hair cells and spiral ganglion neurons due to noise-induced oxidative stress in the cochlea, as well on the impact of cochlear damage on the auditory cortex neurons. The emerging image emphasizes that noise-induced deafferentation and upward spread of cochlear damage is associated with the altered dendritic architecture of auditory pyramidal neurons. The cortical modifications may be reversed by treatment with antioxidants counteracting the cochlear redox imbalance. These findings open new therapeutic approaches to treat the functional consequences of the cortical reorganization following cochlear damage.

KW - Auditory cortex

KW - Noise-induced hearing loss

KW - Oxidative stress

KW - Presbycusis

KW - Pyramidal neurons

UR - http://www.scopus.com/inward/record.url?scp=84924600183&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924600183&partnerID=8YFLogxK

U2 - 10.3389/fnagi.2015.00008

DO - 10.3389/fnagi.2015.00008

M3 - Article

AN - SCOPUS:84924600183

VL - 7

JO - Frontiers in Aging Neuroscience

JF - Frontiers in Aging Neuroscience

SN - 1663-4365

IS - FEB

M1 - 8

ER -