Celiachia, autoimmunita e altro: Sei famiglie e una lettera

Six families are described where more than one component was diagnosed as coeliac. The reported cases provide strong evidence of both the genetic background and the broad clinical spectrum of gluten intolerance. Most cases did not show any gastrointestinal symptom and were diagnosed as a consequence of serological screening (EMA, htTG antibodies). Unexplained anemia, autoimmune disorders, multiple abortions were the conditions most frequently related to hidden gluten intolerance. Human tissue transglutaminase antibodies (htTG) showed an higher sensitivity in comparison to EMA in detecting familial cases of coeliac disease.