Coelodiol and coeloic acid, ent-isocopalane diterpenes from the Indonesian sponge Coelocarteria cfr. singaporensis

Ernesto Fattorusso, Adriana Romano, Orazio Taglialatela-Scafati, Giorgio Bavestrello, Patrizia Bonelli, Barbara Calcinai

Research output: Contribution to journalArticlepeer-review

Abstract

Two novel ent-isocopalane diterpenes, coelodiol (1) and coeloic acid (2), the latter characterized by an unique oxidative degradation of ring A, have been isolated from the Indonesian sponge Coelocarteria cfr. singaporensis. The stereostructure of these metabolites has been established through interpretation of NMR data and application of the exciton chirality CD method. Coelodiol (1) and coeloic acids (2) were found to inhibit the growth of MKN-45 cell line (human gastric adenocarcinoma).

Original languageEnglish
Pages (from-to)2197-2200
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number13
DOIs
Publication statusPublished - Mar 27 2006

Keywords

  • Coelocarteria cfr. singaporensis
  • Diterpenes
  • ent-Isocopalane
  • Exciton chirality
  • Indonesia
  • NMR
  • Structure elucidation

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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