Coelodiol and coeloic acid, ent-isocopalane diterpenes from the Indonesian sponge Coelocarteria cfr. singaporensis

Ernesto Fattorusso; Adriana Romano; Orazio Taglialatela-Scafati; Giorgio Bavestrello; Patrizia Bonelli; Barbara Calcinai

doi:10.1016/j.tetlet.2006.01.109

Coelodiol and coeloic acid, ent-isocopalane diterpenes from the Indonesian sponge Coelocarteria cfr. singaporensis

Ernesto Fattorusso, Adriana Romano, Orazio Taglialatela-Scafati, Giorgio Bavestrello, Patrizia Bonelli, Barbara Calcinai

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

Two novel ent-isocopalane diterpenes, coelodiol (1) and coeloic acid (2), the latter characterized by an unique oxidative degradation of ring A, have been isolated from the Indonesian sponge Coelocarteria cfr. singaporensis. The stereostructure of these metabolites has been established through interpretation of NMR data and application of the exciton chirality CD method. Coelodiol (1) and coeloic acids (2) were found to inhibit the growth of MKN-45 cell line (human gastric adenocarcinoma).

Original language	English
Pages (from-to)	2197-2200
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	13
DOIs	https://doi.org/10.1016/j.tetlet.2006.01.109
Publication status	Published - Mar 27 2006

Keywords

Coelocarteria cfr. singaporensis
Diterpenes
ent-Isocopalane
Exciton chirality
Indonesia
NMR
Structure elucidation

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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Coelodiol and coeloic acid, ent-isocopalane diterpenes from the Indonesian sponge Coelocarteria cfr. singaporensis. / Fattorusso, Ernesto; Romano, Adriana; Taglialatela-Scafati, Orazio; Bavestrello, Giorgio; Bonelli, Patrizia; Calcinai, Barbara.

In: Tetrahedron Letters, Vol. 47, No. 13, 27.03.2006, p. 2197-2200.

Research output: Contribution to journal › Article › peer-review

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abstract = "Two novel ent-isocopalane diterpenes, coelodiol (1) and coeloic acid (2), the latter characterized by an unique oxidative degradation of ring A, have been isolated from the Indonesian sponge Coelocarteria cfr. singaporensis. The stereostructure of these metabolites has been established through interpretation of NMR data and application of the exciton chirality CD method. Coelodiol (1) and coeloic acids (2) were found to inhibit the growth of MKN-45 cell line (human gastric adenocarcinoma).",

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AU - Taglialatela-Scafati, Orazio

AU - Bavestrello, Giorgio

AU - Bonelli, Patrizia

AU - Calcinai, Barbara

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