Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy.

B. Barbiroli, C. Frassineti, P. Martinelli, S. Iotti, R. Lodi, P. Cortelli, P. Montagna

Research output: Contribution to journalArticle

Abstract

With phosphorus magnetic resonance spectroscopy (31P-MRS) we studied in vivo the effect of six-month coenzyme Q10 treatment on the efficiency of brain and skeletal muscle mitochondrial respiration in six patients with different mitochondrial cytopathies. Before CoQ we found a low phosphocreatine content (average of 25% decrease from controls) in the occipital lobes of all patients. Calculated [ADP] and the relative rate of ATP synthesis were high (as an average, 57% and 16% above control group respectively), whereas the cytosolic phosphorylation potential was low (as an average, 60% of control value). 31P-MRS also revealed an average of 29% reduction of the mitochondrial function in the skeletal muscle of patients compared with controls. After a six-month treatment with 150 mg CoQ10/day all brain variables were remarkably improved in all patients, returning within the control range in all cases. Treatment with CoQ also improved the muscle mitochondrial functionality enough to reduce the average deficit to 56% of the control group. These in vivo findings show the beneficial effect of CoQ in patients with mitochondrial cytopathies, and are consistent with the view that increased CoQ concentration in the mitochondrial membrane increases the efficiency of oxidative phosphorylation independently of enzyme deficit.

Original languageEnglish
Pages (from-to)741-749
Number of pages9
JournalCellular and Molecular Biology
Volume43
Issue number5
Publication statusPublished - Jul 1997

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coenzyme Q10
Magnetic resonance spectroscopy
Muscle
Brain
Respiration
Skeletal Muscle
Magnetic Resonance Spectroscopy
Occipital Lobe
Control Groups
Phosphocreatine
Oxidative Phosphorylation
Mitochondrial Membranes
Phosphorylation
Adenosine Diphosphate
Phosphorus
Therapeutics
Adenosine Triphosphate
Mitochondrial cytopathy
Muscles

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Cite this

Coenzyme Q10 improves mitochondrial respiration in patients with mitochondrial cytopathies. An in vivo study on brain and skeletal muscle by phosphorous magnetic resonance spectroscopy. / Barbiroli, B.; Frassineti, C.; Martinelli, P.; Iotti, S.; Lodi, R.; Cortelli, P.; Montagna, P.

In: Cellular and Molecular Biology, Vol. 43, No. 5, 07.1997, p. 741-749.

Research output: Contribution to journalArticle

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