Coexistence of migraine and cluster headache: Report of 10 cases and possible pathogenetic implications

Domenico D'Amico, Vincenzo Centonze, Licia Grazzi, Massimo Leone, Giuseppe Ricchetti, Gennaro Bussone

Research output: Contribution to journalArticlepeer-review


We report on 10 patients suffering from two types of primary headache, migraine and cluster, diagnosed according to (HS criteria, and selected from headache patients attending two Italian headache centers. We briefly review the literature on coexisting migraine and cluster headache, considering the time relationships between these two headaches. The present series seems not to confirm the hypothesis that migraine transforms into cluster headache since both headaches persist together in the patients. The series is of clinical interest particularly with regard to diagnosis end to treatment strategies. Furthermore, while migraine and cluster headache comorbidity must be confirmed by population-based epidemiological studies, the possibility arises that the two conditions may be linked pathophysiologically: common genetic factors or functional alterations in the same central neurological circuits may play a role in the pathogenesis of both disorders.

Original languageEnglish
Pages (from-to)21-25
Number of pages5
Issue number1
Publication statusPublished - Jan 1997


  • cluster headache
  • comorbidity
  • migraine
  • pathophysiology
  • time relationships
  • treatment

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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