Coexpression of TGFα, epidermal growth factor receptor, and P-glycoprotein in normal and benign diseased breast tissues

Stefania Scala, Toshiaki Saeki, Anika Lynch, David Salomon, Maria J. Merino, Susan E. Bates

Research output: Contribution to journalArticlepeer-review

Abstract

Twenty-four normal or benign breast tissues were examined for the expression of transforming growth factor-a (TGFa), epidermal growth factor receptor (EGFR), and P-glycoprotein, the product of the mdr-\ gene. Specific staining for all three proteins was observed in the majority of the samples. P-glycoprotein staining was present in most (88%), and confined to the lumenal surface of the ductal epithelium. Membranous EGFR expression was observed in epithelial cells in 92% of the specimens and 42% displayed both myoepithelial and epithelial cell staining. TGFa staining was intense and uniformly distributed through the cytoplasm (96%). Coexpression of EGFR, TGFa, and P-glycoprotein in normal human breast tissues suggests a role for each of those proteins in normal breast physiology. An interaction may be present in normal breast tissue between the EGF receptor pathway and P-glycoprotein.

Original languageEnglish
Pages (from-to)136-142
Number of pages7
JournalDiagnostic Molecular Pathology
Volume4
Issue number2
Publication statusPublished - 1995

Keywords

  • Breast tissue
  • EGFR
  • Immunostaining
  • P-glycoprotein
  • TGFα

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine

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