Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Raul Zamora-Ros, Muath A. Alghamdi, Valerie Cayssials, Silvia Franceschi, Martin Almquist, Joakim Hennings, Maria Sandström, Konstantinos K. Tsilidis, Elisabete Weiderpass, Marie Christine Boutron-Ruault, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Kristina E.N. Petersen, Francesca Romana Mancini, Yahya Mahamat-Saleh, Fabrice Bonnet, Tilman Kühn, Renée T. Fortner, Heiner BoeingAntonia Trichopoulou, Christina Bamia, Georgia Martimianaki, Giovanna Masala, Sara Grioni, Salvatore Panico, Rosario Tumino, Francesca Fasanelli, Guri Skeie, Tonje Braaten, Cristina Lasheras, Elena Salamanca-Fernández, Pilar Amiano, Maria Dolores Chirlaque, Aurelio Barricarte, Jonas Manjer, Peter Wallström, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Kay Thee Khaw, Nicholas J. Wareham, Julie A. Schmidt, Dagfinn Aune, Graham Byrnes, Augustin Scalbert, Antonio Agudo, Sabina Rinaldi

Research output: Contribution to journalArticle

Abstract

Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases. Conclusions: In this large prospective study, coffee and tea consumptions were not associated with TC risk.

Original languageEnglish
Pages (from-to)3303-3312
Number of pages10
JournalEuropean Journal of Nutrition
Volume58
Issue number8
DOIs
Publication statusPublished - Dec 1 2019

Keywords

  • Coffee
  • Cohort
  • EPIC
  • Intake
  • Tea
  • Thyroid cancer

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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    Zamora-Ros, R., Alghamdi, M. A., Cayssials, V., Franceschi, S., Almquist, M., Hennings, J., Sandström, M., Tsilidis, K. K., Weiderpass, E., Boutron-Ruault, M. C., Hammer Bech, B., Overvad, K., Tjønneland, A., Petersen, K. E. N., Mancini, F. R., Mahamat-Saleh, Y., Bonnet, F., Kühn, T., Fortner, R. T., ... Rinaldi, S. (2019). Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma: results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study. European Journal of Nutrition, 58(8), 3303-3312. https://doi.org/10.1007/s00394-018-1874-z