Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies

Francesca Bravi, Alessandra Tavani, Cristina Bosetti, Paolo Boffetta, Carlo la Vecchia

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

An inverse association has been reported between coffee drinking and the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but its magnitude is still unclear. Thus, we carried out a systematic review and meta-analysis of prospective cohort studies that investigated the association between coffee consumption and the risk of HCC or CLD. We separately estimated the relative risk (RR) of the two conditions, for regular, low, and high consumption compared with no or occasional coffee consumption; we also calculated the summary RR for an increment of one cup of coffee per day. Twelve studies on HCC (3414 cases) and six studies on CLD (1463 cases) were identified. The summary RRs for HCC were 0.66 [95% confidence interval (CI): 0.55–0.78] for regular, 0.78 (95% CI: 0.66–0.91) for low, and 0.50 (95% CI: 0.43–0.58) for high coffee consumption, respectively. The summary RR for an increment of one cup per day was 0.85 (95% CI: 0.81–0.90). The summary RRs for CLD were 0.62 (95% CI: 0.47–0.82) for regular, 0.72 (95% CI: 0.59–0.88) for low, 0.35 (95% CI: 0.22–0.56) for high, and 0.74 (95% CI: 0.65–0.83) for an increment of one cup per day. The present meta-analysis provides a precise quantification of the inverse relation between coffee consumption and the risk of HCC, and adds evidence to the presence of an even stronger negative association with CLD.

Original languageEnglish
JournalEuropean Journal of Cancer Prevention
DOIs
Publication statusAccepted/In press - Apr 22 2016

Fingerprint

Coffee
Meta-Analysis
Liver Diseases
Hepatocellular Carcinoma
Chronic Disease
Prospective Studies
Confidence Intervals
Drinking
Cohort Studies

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Epidemiology
  • Public Health, Environmental and Occupational Health

Cite this

Coffee and the risk of hepatocellular carcinoma and chronic liver disease : a systematic review and meta-analysis of prospective studies. / Bravi, Francesca; Tavani, Alessandra; Bosetti, Cristina; Boffetta, Paolo; la Vecchia, Carlo.

In: European Journal of Cancer Prevention, 22.04.2016.

Research output: Contribution to journalArticle

@article{f311aaebc32140579354b134b9630909,
title = "Coffee and the risk of hepatocellular carcinoma and chronic liver disease: a systematic review and meta-analysis of prospective studies",
abstract = "An inverse association has been reported between coffee drinking and the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but its magnitude is still unclear. Thus, we carried out a systematic review and meta-analysis of prospective cohort studies that investigated the association between coffee consumption and the risk of HCC or CLD. We separately estimated the relative risk (RR) of the two conditions, for regular, low, and high consumption compared with no or occasional coffee consumption; we also calculated the summary RR for an increment of one cup of coffee per day. Twelve studies on HCC (3414 cases) and six studies on CLD (1463 cases) were identified. The summary RRs for HCC were 0.66 [95{\%} confidence interval (CI): 0.55–0.78] for regular, 0.78 (95{\%} CI: 0.66–0.91) for low, and 0.50 (95{\%} CI: 0.43–0.58) for high coffee consumption, respectively. The summary RR for an increment of one cup per day was 0.85 (95{\%} CI: 0.81–0.90). The summary RRs for CLD were 0.62 (95{\%} CI: 0.47–0.82) for regular, 0.72 (95{\%} CI: 0.59–0.88) for low, 0.35 (95{\%} CI: 0.22–0.56) for high, and 0.74 (95{\%} CI: 0.65–0.83) for an increment of one cup per day. The present meta-analysis provides a precise quantification of the inverse relation between coffee consumption and the risk of HCC, and adds evidence to the presence of an even stronger negative association with CLD.",
author = "Francesca Bravi and Alessandra Tavani and Cristina Bosetti and Paolo Boffetta and {la Vecchia}, Carlo",
year = "2016",
month = "4",
day = "22",
doi = "10.1097/CEJ.0000000000000252",
language = "English",
journal = "European Journal of Cancer Prevention",
issn = "0959-8278",
publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Coffee and the risk of hepatocellular carcinoma and chronic liver disease

T2 - a systematic review and meta-analysis of prospective studies

AU - Bravi, Francesca

AU - Tavani, Alessandra

AU - Bosetti, Cristina

AU - Boffetta, Paolo

AU - la Vecchia, Carlo

PY - 2016/4/22

Y1 - 2016/4/22

N2 - An inverse association has been reported between coffee drinking and the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but its magnitude is still unclear. Thus, we carried out a systematic review and meta-analysis of prospective cohort studies that investigated the association between coffee consumption and the risk of HCC or CLD. We separately estimated the relative risk (RR) of the two conditions, for regular, low, and high consumption compared with no or occasional coffee consumption; we also calculated the summary RR for an increment of one cup of coffee per day. Twelve studies on HCC (3414 cases) and six studies on CLD (1463 cases) were identified. The summary RRs for HCC were 0.66 [95% confidence interval (CI): 0.55–0.78] for regular, 0.78 (95% CI: 0.66–0.91) for low, and 0.50 (95% CI: 0.43–0.58) for high coffee consumption, respectively. The summary RR for an increment of one cup per day was 0.85 (95% CI: 0.81–0.90). The summary RRs for CLD were 0.62 (95% CI: 0.47–0.82) for regular, 0.72 (95% CI: 0.59–0.88) for low, 0.35 (95% CI: 0.22–0.56) for high, and 0.74 (95% CI: 0.65–0.83) for an increment of one cup per day. The present meta-analysis provides a precise quantification of the inverse relation between coffee consumption and the risk of HCC, and adds evidence to the presence of an even stronger negative association with CLD.

AB - An inverse association has been reported between coffee drinking and the risk of hepatocellular carcinoma (HCC) and chronic liver disease (CLD), but its magnitude is still unclear. Thus, we carried out a systematic review and meta-analysis of prospective cohort studies that investigated the association between coffee consumption and the risk of HCC or CLD. We separately estimated the relative risk (RR) of the two conditions, for regular, low, and high consumption compared with no or occasional coffee consumption; we also calculated the summary RR for an increment of one cup of coffee per day. Twelve studies on HCC (3414 cases) and six studies on CLD (1463 cases) were identified. The summary RRs for HCC were 0.66 [95% confidence interval (CI): 0.55–0.78] for regular, 0.78 (95% CI: 0.66–0.91) for low, and 0.50 (95% CI: 0.43–0.58) for high coffee consumption, respectively. The summary RR for an increment of one cup per day was 0.85 (95% CI: 0.81–0.90). The summary RRs for CLD were 0.62 (95% CI: 0.47–0.82) for regular, 0.72 (95% CI: 0.59–0.88) for low, 0.35 (95% CI: 0.22–0.56) for high, and 0.74 (95% CI: 0.65–0.83) for an increment of one cup per day. The present meta-analysis provides a precise quantification of the inverse relation between coffee consumption and the risk of HCC, and adds evidence to the presence of an even stronger negative association with CLD.

UR - http://www.scopus.com/inward/record.url?scp=84964285857&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84964285857&partnerID=8YFLogxK

U2 - 10.1097/CEJ.0000000000000252

DO - 10.1097/CEJ.0000000000000252

M3 - Article

AN - SCOPUS:84964285857

JO - European Journal of Cancer Prevention

JF - European Journal of Cancer Prevention

SN - 0959-8278

ER -