Coffee consumption and digestive tract cancers

C. La Vecchia, M. Ferraroni, E. Negri, B. D'Avanzo, A. Decarli, F. Levi, S. Franceschi

Research output: Contribution to journalArticle

Abstract

The relationship between coffee drinking and the risk of digestive tract neoplasms was analyzed in a case-control study of 50 cases of cancer of the mouth or pharynx, 209 of the esophagus, 397 of the stomach, 455 of the colon, 295 of the rectum, 151 of the liver, 214 of the pancreas, and 1944 control subjects admitted for acute, non-digestive tract disorders. There was no significant or consistent association between coffee and cancers of the mouth or pharynx, esophagus, stomach, liver, or pancreas. In particular, for pancreatic cancer, the multivariate relative risks for the intermediate and upper tertiles were 1.05 and 1.01, respectively. There were significant inverse trends in risk with measures of coffee consumption for colon and rectal cancers, the multivariate relative risks according to tertiles of coffee consumption being 0.86 and 0.64 for colon and 0.97 and 0.66 for rectum. This apparent protection is in agreement with some (but not all) previous epidemiological evidence and finds a possible biological interpretation in terms of interference on bile secretion, causing reduced bile acid and neutral sterol concentrations in the bowel. In conclusion, the results of this study, the major interest of which lies in the opportunity of drawing up an overall pattern of risk for various digestive neoplasms, offer further reassurance as regards the effects of coffee on digestive tract carcinogenesis.

Original languageEnglish
Pages (from-to)1049-1051
Number of pages3
JournalCancer Research
Volume49
Issue number4
Publication statusPublished - 1989

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Coffee
Gastrointestinal Tract
Pharyngeal Neoplasms
Mouth Neoplasms
Neoplasms
Rectum
Esophagus
Pancreas
Stomach
Colon
Liver
Sterols
Rectal Neoplasms
Bile Acids and Salts
Pancreatic Neoplasms
Bile
Colonic Neoplasms
Drinking
Case-Control Studies
Carcinogenesis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

La Vecchia, C., Ferraroni, M., Negri, E., D'Avanzo, B., Decarli, A., Levi, F., & Franceschi, S. (1989). Coffee consumption and digestive tract cancers. Cancer Research, 49(4), 1049-1051.

Coffee consumption and digestive tract cancers. / La Vecchia, C.; Ferraroni, M.; Negri, E.; D'Avanzo, B.; Decarli, A.; Levi, F.; Franceschi, S.

In: Cancer Research, Vol. 49, No. 4, 1989, p. 1049-1051.

Research output: Contribution to journalArticle

La Vecchia, C, Ferraroni, M, Negri, E, D'Avanzo, B, Decarli, A, Levi, F & Franceschi, S 1989, 'Coffee consumption and digestive tract cancers', Cancer Research, vol. 49, no. 4, pp. 1049-1051.
La Vecchia C, Ferraroni M, Negri E, D'Avanzo B, Decarli A, Levi F et al. Coffee consumption and digestive tract cancers. Cancer Research. 1989;49(4):1049-1051.
La Vecchia, C. ; Ferraroni, M. ; Negri, E. ; D'Avanzo, B. ; Decarli, A. ; Levi, F. ; Franceschi, S. / Coffee consumption and digestive tract cancers. In: Cancer Research. 1989 ; Vol. 49, No. 4. pp. 1049-1051.
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