Coffee consumption and risk of non-Hodgkin's lymphoma: evidence from the Italian multicentre case-control study

Stefano Parodi, Franco Domenico Merlo, Emanuele Stagnaro, Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy, Oriana Nanni

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

PURPOSE: Several investigations have analysed the association between coffee intake and risk of cancer. Contradictory results were reported by the studies conducted in non-Hodgkin's lymphomas (NHL) few of which report results according to main NHL subgroups. The present study is aimed at evaluating the association between coffee consumption and the risk of NHL by analysing data from a large Italian multicentre case-control study that included 1,418 interviewed cases (1,301 B cell and 117 T cell NHL), diagnosed between 1990 and 1993, and 1,774 population healthy controls.

METHODS: The association was evaluated by standard logistic regression analysis. Odds ratio (OR) estimates were adjusted for gender, age, residence area, educational level, previous chemotherapy treatment, smoking habit and exposure to electromagnetic fields, radiation, pesticides and aromatic hydrocarbons.

RESULTS: For all B cell lymphomas, an increased risk (OR 1.6, 95% CI 1.2-2.0) was observed in the highest exposure category (consumption >4 cups per day for at least 30 years), but without a clear dose-response trend. Subgroup analyses highlighted an increased risk for drinkers of at least four cups per day for follicular lymphoma (OR 2.0, 95% CI 1.2-3.4). The risk increased with years of exposure and was more elevated among current smokers.

CONCLUSIONS: Consumption of more than four cups of coffee per day enhances the risk of lymphoma, especially the follicular subtype. Further investigations based on large cohorts and accurate measures of exposure are needed to confirm the observed associations.

Original languageEnglish
Pages (from-to)867-876
Number of pages10
JournalCancer Causes and Control
Volume28
Issue number8
DOIs
Publication statusPublished - Aug 2017

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Coffee
Non-Hodgkin's Lymphoma
Case-Control Studies
Odds Ratio
Follicular Lymphoma
Electromagnetic Radiation
Aromatic Hydrocarbons
Electromagnetic Fields
Population Control
T-Cell Lymphoma
B-Cell Lymphoma
Pesticides
Habits
B-Lymphocytes
Logistic Models
Smoking
Regression Analysis
Drug Therapy
Neoplasms

Keywords

  • Adult
  • Aged
  • Case-Control Studies
  • Coffee
  • Female
  • Humans
  • Italy
  • Lymphoma, Non-Hodgkin
  • Male
  • Middle Aged
  • Odds Ratio
  • Risk
  • Smoking
  • Young Adult
  • Journal Article

Cite this

Parodi, S., Merlo, F. D., Stagnaro, E., Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy, & Nanni, O. (2017). Coffee consumption and risk of non-Hodgkin's lymphoma: evidence from the Italian multicentre case-control study. Cancer Causes and Control, 28(8), 867-876. https://doi.org/10.1007/s10552-017-0909-8

Coffee consumption and risk of non-Hodgkin's lymphoma : evidence from the Italian multicentre case-control study. / Parodi, Stefano; Merlo, Franco Domenico; Stagnaro, Emanuele; Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy ; Nanni, Oriana.

In: Cancer Causes and Control, Vol. 28, No. 8, 08.2017, p. 867-876.

Research output: Contribution to journalArticle

Parodi, S, Merlo, FD, Stagnaro, E, Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy & Nanni, O 2017, 'Coffee consumption and risk of non-Hodgkin's lymphoma: evidence from the Italian multicentre case-control study', Cancer Causes and Control, vol. 28, no. 8, pp. 867-876. https://doi.org/10.1007/s10552-017-0909-8
Parodi S, Merlo FD, Stagnaro E, Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy, Nanni O. Coffee consumption and risk of non-Hodgkin's lymphoma: evidence from the Italian multicentre case-control study. Cancer Causes and Control. 2017 Aug;28(8):867-876. https://doi.org/10.1007/s10552-017-0909-8
Parodi, Stefano ; Merlo, Franco Domenico ; Stagnaro, Emanuele ; Working Group for the Epidemiology of Hematolymphopoietic Malignancies in Italy ; Nanni, Oriana. / Coffee consumption and risk of non-Hodgkin's lymphoma : evidence from the Italian multicentre case-control study. In: Cancer Causes and Control. 2017 ; Vol. 28, No. 8. pp. 867-876.
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N2 - PURPOSE: Several investigations have analysed the association between coffee intake and risk of cancer. Contradictory results were reported by the studies conducted in non-Hodgkin's lymphomas (NHL) few of which report results according to main NHL subgroups. The present study is aimed at evaluating the association between coffee consumption and the risk of NHL by analysing data from a large Italian multicentre case-control study that included 1,418 interviewed cases (1,301 B cell and 117 T cell NHL), diagnosed between 1990 and 1993, and 1,774 population healthy controls.METHODS: The association was evaluated by standard logistic regression analysis. Odds ratio (OR) estimates were adjusted for gender, age, residence area, educational level, previous chemotherapy treatment, smoking habit and exposure to electromagnetic fields, radiation, pesticides and aromatic hydrocarbons.RESULTS: For all B cell lymphomas, an increased risk (OR 1.6, 95% CI 1.2-2.0) was observed in the highest exposure category (consumption >4 cups per day for at least 30 years), but without a clear dose-response trend. Subgroup analyses highlighted an increased risk for drinkers of at least four cups per day for follicular lymphoma (OR 2.0, 95% CI 1.2-3.4). The risk increased with years of exposure and was more elevated among current smokers.CONCLUSIONS: Consumption of more than four cups of coffee per day enhances the risk of lymphoma, especially the follicular subtype. Further investigations based on large cohorts and accurate measures of exposure are needed to confirm the observed associations.

AB - PURPOSE: Several investigations have analysed the association between coffee intake and risk of cancer. Contradictory results were reported by the studies conducted in non-Hodgkin's lymphomas (NHL) few of which report results according to main NHL subgroups. The present study is aimed at evaluating the association between coffee consumption and the risk of NHL by analysing data from a large Italian multicentre case-control study that included 1,418 interviewed cases (1,301 B cell and 117 T cell NHL), diagnosed between 1990 and 1993, and 1,774 population healthy controls.METHODS: The association was evaluated by standard logistic regression analysis. Odds ratio (OR) estimates were adjusted for gender, age, residence area, educational level, previous chemotherapy treatment, smoking habit and exposure to electromagnetic fields, radiation, pesticides and aromatic hydrocarbons.RESULTS: For all B cell lymphomas, an increased risk (OR 1.6, 95% CI 1.2-2.0) was observed in the highest exposure category (consumption >4 cups per day for at least 30 years), but without a clear dose-response trend. Subgroup analyses highlighted an increased risk for drinkers of at least four cups per day for follicular lymphoma (OR 2.0, 95% CI 1.2-3.4). The risk increased with years of exposure and was more elevated among current smokers.CONCLUSIONS: Consumption of more than four cups of coffee per day enhances the risk of lymphoma, especially the follicular subtype. Further investigations based on large cohorts and accurate measures of exposure are needed to confirm the observed associations.

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