TY - JOUR
T1 - Coffee consumption habits and the risk of mild cognitive impairment
T2 - The Italian longitudinal study on aging
AU - Solfrizzi, Vincenzo
AU - Panza, Francesco
AU - Imbimbo, Bruno P.
AU - D'Introno, Alessia
AU - Galluzzo, Lucia
AU - Gandin, Claudia
AU - Misciagna, Giovanni
AU - Guerra, Vito
AU - Osella, Alberto
AU - Baldereschi, Marzia
AU - Di Carlo, Antonio
AU - Inzitari, Domenico
AU - Seripa, Davide
AU - Pilotto, Alberto
AU - Sabbá, Carlo
AU - Logroscino, Giancarlo
AU - Scafato, Emanuele
PY - 2015/8/11
Y1 - 2015/8/11
N2 - Coffee, tea, or caffeine consumption may be protective against cognitive impairment and dementia.We estimated the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI). We evaluated 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging, a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. Cognitively normal older individuals who habitually consumed moderate amount of coffee (from 1 to 2 cups of coffee/day) had a lower rate of the incidence of MCI than those who never or rarely consumed coffee [1 cup/day: hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.211 to 1.02 or 1-2 cups/day: HR: 0.31 95% CI: 0.13 to 0.75]. For cognitively normal older subjects who changed their coffee consumption habits, those increasing coffee consumption (>1 cup of coffee/day) had higher rate of the incidence of MCI compared to those with constant habits (up to±1 cup of coffee/day) (HR: 1.80, 95% CI: 1.11 to 2.92) or those with reduced consumption (2 cups of coffee/day) and the incidence of MCI in comparison with those who never or rarely consumed coffee (HR: 0.26, 95% CI: 0.03 to 2.11). In conclusion, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing MCI, while a constant in time moderate coffee consumption was associated to a reduced rate of the incidence of MCI.
AB - Coffee, tea, or caffeine consumption may be protective against cognitive impairment and dementia.We estimated the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI). We evaluated 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging, a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. Cognitively normal older individuals who habitually consumed moderate amount of coffee (from 1 to 2 cups of coffee/day) had a lower rate of the incidence of MCI than those who never or rarely consumed coffee [1 cup/day: hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.211 to 1.02 or 1-2 cups/day: HR: 0.31 95% CI: 0.13 to 0.75]. For cognitively normal older subjects who changed their coffee consumption habits, those increasing coffee consumption (>1 cup of coffee/day) had higher rate of the incidence of MCI compared to those with constant habits (up to±1 cup of coffee/day) (HR: 1.80, 95% CI: 1.11 to 2.92) or those with reduced consumption (2 cups of coffee/day) and the incidence of MCI in comparison with those who never or rarely consumed coffee (HR: 0.26, 95% CI: 0.03 to 2.11). In conclusion, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing MCI, while a constant in time moderate coffee consumption was associated to a reduced rate of the incidence of MCI.
KW - Alzheimer's disease
KW - Caffeine use
KW - Coffee consumption
KW - Dementia
KW - Mild cognitive impairment
UR - http://www.scopus.com/inward/record.url?scp=84939438686&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84939438686&partnerID=8YFLogxK
U2 - 10.3233/JAD-150333
DO - 10.3233/JAD-150333
M3 - Article
C2 - 26401769
AN - SCOPUS:84939438686
VL - 47
SP - 889
EP - 899
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 4
ER -