Coffee consumption habits and the risk of mild cognitive impairment: The Italian longitudinal study on aging

Vincenzo Solfrizzi, Francesco Panza, Bruno P. Imbimbo, Alessia D'Introno, Lucia Galluzzo, Claudia Gandin, Giovanni Misciagna, Vito Guerra, Alberto Osella, Marzia Baldereschi, Antonio Di Carlo, Domenico Inzitari, Davide Seripa, Alberto Pilotto, Carlo Sabbá, Giancarlo Logroscino, Emanuele Scafato

Research output: Contribution to journalArticlepeer-review


Coffee, tea, or caffeine consumption may be protective against cognitive impairment and dementia.We estimated the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI). We evaluated 1,445 individuals recruited from 5,632 subjects, aged 65-84 year old, from the Italian Longitudinal Study on Aging, a population-based sample from eight Italian municipalities with a 3.5-year median follow-up. Cognitively normal older individuals who habitually consumed moderate amount of coffee (from 1 to 2 cups of coffee/day) had a lower rate of the incidence of MCI than those who never or rarely consumed coffee [1 cup/day: hazard ratio (HR): 0.47, 95% confidence interval (CI): 0.211 to 1.02 or 1-2 cups/day: HR: 0.31 95% CI: 0.13 to 0.75]. For cognitively normal older subjects who changed their coffee consumption habits, those increasing coffee consumption (>1 cup of coffee/day) had higher rate of the incidence of MCI compared to those with constant habits (up to±1 cup of coffee/day) (HR: 1.80, 95% CI: 1.11 to 2.92) or those with reduced consumption (2 cups of coffee/day) and the incidence of MCI in comparison with those who never or rarely consumed coffee (HR: 0.26, 95% CI: 0.03 to 2.11). In conclusion, cognitively normal older individuals who increased their coffee consumption had a higher rate of developing MCI, while a constant in time moderate coffee consumption was associated to a reduced rate of the incidence of MCI.

Original languageEnglish
Pages (from-to)889-899
Number of pages11
JournalJournal of Alzheimer's Disease
Issue number4
Publication statusPublished - Aug 11 2015


  • Alzheimer's disease
  • Caffeine use
  • Coffee consumption
  • Dementia
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


Dive into the research topics of 'Coffee consumption habits and the risk of mild cognitive impairment: The Italian longitudinal study on aging'. Together they form a unique fingerprint.

Cite this