Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies

Massimiliano Berretta; Agnieszka Micek; Alessandra Lafranconi; Sabrina Rossetti; Raffaele Di Francia; Paolo De Paoli; Paola Rossi; Gaetano Facchini

doi:10.18632/oncotarget.24829

Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies

Massimiliano Berretta, Agnieszka Micek, Alessandra Lafranconi, Sabrina Rossetti, Raffaele Di Francia, Paolo De Paoli, Paola Rossi, Gaetano Facchini

Research output: Contribution to journal › Article

Abstract

Background: Coffee consumption has been associated with numerous cancers, but evidence on ovarian cancer risk is controversial. Therefore, we performed a meta-analysis on prospective cohort studies in order to review the evidence on coffee consumption and risk of ovarian cancer.

Methods: Studies were identified through searching the PubMed and MEDLINE databases up to March 2017. Risk estimates were retrieved from the studies, and dose-response analysis was modelled by using restricted cubic splines. Additionally, a stratified analysis by menopausal status was performed.

Results: A total of 8 studies were eligible for the dose-response meta-analysis. Studies included in the analysis comprised 787,076 participants and 3,541 ovarian cancer cases. The results showed that coffee intake was not associated with ovarian cancer risk (RR = 1.06, 95% CI: 0.89, 1.26). Stratified and subgroup analysis showed consisted results.

Conclusions: This comprehensive meta-analysis did not find evidence of an association between the consumption of coffee and risk of ovarian cancer.

Original language	English
Pages (from-to)	20807-20815
Number of pages	9
Journal	Oncotarget
Volume	9
Issue number	29
DOIs	https://doi.org/10.18632/oncotarget.24829
Publication status	Published - Apr 17 2018

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Berretta, M., Micek, A., Lafranconi, A., Rossetti, S., Di Francia, R., De Paoli, P., Rossi, P., & Facchini, G. (2018). Coffee consumption is not associated with ovarian cancer risk: a dose-response meta-analysis of prospective cohort studies. Oncotarget, 9(29), 20807-20815. https://doi.org/10.18632/oncotarget.24829

Coffee consumption is not associated with ovarian cancer risk : a dose-response meta-analysis of prospective cohort studies. / Berretta, Massimiliano; Micek, Agnieszka; Lafranconi, Alessandra; Rossetti, Sabrina; Di Francia, Raffaele; De Paoli, Paolo; Rossi, Paola; Facchini, Gaetano.

In: Oncotarget, Vol. 9, No. 29, 17.04.2018, p. 20807-20815.

Research output: Contribution to journal › Article

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abstract = "Background: Coffee consumption has been associated with numerous cancers, but evidence on ovarian cancer risk is controversial. Therefore, we performed a meta-analysis on prospective cohort studies in order to review the evidence on coffee consumption and risk of ovarian cancer.Methods: Studies were identified through searching the PubMed and MEDLINE databases up to March 2017. Risk estimates were retrieved from the studies, and dose-response analysis was modelled by using restricted cubic splines. Additionally, a stratified analysis by menopausal status was performed.Results: A total of 8 studies were eligible for the dose-response meta-analysis. Studies included in the analysis comprised 787,076 participants and 3,541 ovarian cancer cases. The results showed that coffee intake was not associated with ovarian cancer risk (RR = 1.06, 95% CI: 0.89, 1.26). Stratified and subgroup analysis showed consisted results.Conclusions: This comprehensive meta-analysis did not find evidence of an association between the consumption of coffee and risk of ovarian cancer.",

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AU - Berretta, Massimiliano

AU - Micek, Agnieszka

AU - Lafranconi, Alessandra

AU - Rossetti, Sabrina

AU - Di Francia, Raffaele

AU - De Paoli, Paolo

AU - Rossi, Paola

AU - Facchini, Gaetano

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AB - Background: Coffee consumption has been associated with numerous cancers, but evidence on ovarian cancer risk is controversial. Therefore, we performed a meta-analysis on prospective cohort studies in order to review the evidence on coffee consumption and risk of ovarian cancer.Methods: Studies were identified through searching the PubMed and MEDLINE databases up to March 2017. Risk estimates were retrieved from the studies, and dose-response analysis was modelled by using restricted cubic splines. Additionally, a stratified analysis by menopausal status was performed.Results: A total of 8 studies were eligible for the dose-response meta-analysis. Studies included in the analysis comprised 787,076 participants and 3,541 ovarian cancer cases. The results showed that coffee intake was not associated with ovarian cancer risk (RR = 1.06, 95% CI: 0.89, 1.26). Stratified and subgroup analysis showed consisted results.Conclusions: This comprehensive meta-analysis did not find evidence of an association between the consumption of coffee and risk of ovarian cancer.

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