Coffee decreases the risk of endometrial cancer: A dose–response meta-analysis of prospective cohort studies

Alessandra Lafranconi, Agnieszka Micek, Fabio Galvano, Sabrina Rossetti, Lino Del Pup, Massimiliano Berretta, Gaetano Facchini

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Aim: The aim of this study was to perform a comprehensive meta-analysis of the association between coffee consumption and risk of endometrial cancer. Methods: Eligible studies were identified by searching the PubMed and EMBASE databases. The dose–response relationship as well as the risk of endometrial cancer for the highest versus the lowest categories of coffee consumption were assessed. Subgroup analyses considering the menopausal and receptor statuses, the smoking status, and the BMI (Body Mass Index) were performed in order to identify potential confounders. Results: We identified a total of 12 studies eligible for meta-analysis. A dose–response meta-analysis showed a decreased risk of endometrial cancer. Moreover, a subgroup analysis indicated that coffee consumption is significantly associated with a decreased risk of postmenopausal cancer. Increasing coffee consumption by four cups per day was associated with a 20% reduction in endometrial cancer risk (relative risk (RR) 0.80; 95% confidence interval (CI) 0.72 to 0.89) and with a 24% reduction in postmenopausal cancer risk (RR 0.76; 95% CI 0.69 to 0.83). Conclusions: Our findings suggest that increased coffee consumption is associated with decreased risk of endometrial cancer, and this association is observed also for postmenopausal cancer.

Original languageEnglish
Article number1223
JournalNutrients
Volume9
Issue number11
DOIs
Publication statusPublished - Nov 9 2017

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Coffee
Endometrial Neoplasms
cohort studies
meta-analysis
dose response
Meta-Analysis
Cohort Studies
Prospective Studies
neoplasms
risk reduction
relative risk
confidence interval
menopause
Confidence Intervals
Neoplasms
body mass index
PubMed
Body Mass Index
Smoking
Databases

Keywords

  • Caffeine
  • Coffee
  • Endometrial cancer
  • Meta-analysis
  • Postmenopausal
  • Prospective cohort

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

Coffee decreases the risk of endometrial cancer : A dose–response meta-analysis of prospective cohort studies. / Lafranconi, Alessandra; Micek, Agnieszka; Galvano, Fabio; Rossetti, Sabrina; Del Pup, Lino; Berretta, Massimiliano; Facchini, Gaetano.

In: Nutrients, Vol. 9, No. 11, 1223, 09.11.2017.

Research output: Contribution to journalReview article

Lafranconi A, Micek A, Galvano F, Rossetti S, Del Pup L, Berretta M et al. Coffee decreases the risk of endometrial cancer: A dose–response meta-analysis of prospective cohort studies. Nutrients. 2017 Nov 9;9(11). 1223. https://doi.org/10.3390/nu9111223
Lafranconi, Alessandra ; Micek, Agnieszka ; Galvano, Fabio ; Rossetti, Sabrina ; Del Pup, Lino ; Berretta, Massimiliano ; Facchini, Gaetano. / Coffee decreases the risk of endometrial cancer : A dose–response meta-analysis of prospective cohort studies. In: Nutrients. 2017 ; Vol. 9, No. 11.
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