TY - JOUR
T1 - Coffee drinking and endometrial cancer risk
T2 - a metaanalysis of observational studies
AU - Bravi, Francesca
AU - Scotti, Lorenza
AU - Bosetti, Cristina
AU - Gallus, Silvano
AU - Negri, Eva
AU - La Vecchia, Carlo
AU - Tavani, Alessandra
PY - 2008/2
Y1 - 2008/2
N2 - We conducted a metaanalysis of published studies on the relation between coffee drinking and endometrial cancer risk, which included 2 cohort (201 cases) and 7 case-control studies (2409 cases). The summary relative risk (RR) for coffee drinkers vs nondrinkers was 0.80 (95% confidence interval [CI], 0.68-0.94), with significant heterogeneity between studies. Compared with nondrinkers, the summary RR was 0.87 (95% CI, 0.78-0.97) for low-to-moderate coffee drinkers and 0.64 (95% CI, 0.48-0.86) for heavy coffee drinkers. The summary RR for an increase of 1 cup/d was 0.93 (95% CI, 0.89-0.97), which suggests an inverse relation between coffee and endometrial cancer. However, the causality must be confirmed.
AB - We conducted a metaanalysis of published studies on the relation between coffee drinking and endometrial cancer risk, which included 2 cohort (201 cases) and 7 case-control studies (2409 cases). The summary relative risk (RR) for coffee drinkers vs nondrinkers was 0.80 (95% confidence interval [CI], 0.68-0.94), with significant heterogeneity between studies. Compared with nondrinkers, the summary RR was 0.87 (95% CI, 0.78-0.97) for low-to-moderate coffee drinkers and 0.64 (95% CI, 0.48-0.86) for heavy coffee drinkers. The summary RR for an increase of 1 cup/d was 0.93 (95% CI, 0.89-0.97), which suggests an inverse relation between coffee and endometrial cancer. However, the causality must be confirmed.
KW - coffee
KW - endometrial cancer
KW - metaanalysis
KW - risk factor
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U2 - 10.1016/j.ajog.2008.10.032
DO - 10.1016/j.ajog.2008.10.032
M3 - Article
C2 - 19110217
AN - SCOPUS:58749087220
VL - 200
SP - 130
EP - 135
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -