Coffee intake decreases risk of postmenopausal breast cancer: A dose-response meta-analysis on prospective cohort studies

Alessandra Lafranconi, Agnieszka Micek, Paolo De Paoli, Sabrina Bimonte, Paola Rossi, Vincenzo Quagliariello, Massimiliano Berretta

Research output: Contribution to journalArticlepeer-review


Aim: A dose-response meta-analysis was conducted in order to summarize the evidence from prospective cohort studies regarding the association between coffee intake and breast cancer risk. Methods: A systematic search was performed in electronic databases up to March 2017 to identify relevant studies; risk estimates were retrieved from the studies and linear and non-linear dose-response analysis modelled by restricted cubic splines was conducted. A stratified and subgroup analysis by menopausal and estrogen/progesterone receptor (ER/PR) status, smoking status and body mass index (BMI) were performed in order to detect potential confounders. Results: A total of 21 prospective studies were selected either for dose-response, the highest versus lowest category of consumption or subgroup analysis. The dose-response analysis of 13 prospective studies showed no significant association between coffee consumption and breast cancer risk in the non-linear model. However, an inverse relationship has been found when the analysis was restricted to post-menopausal women. Consumption of four cups of coffee per day was associated with a 10% reduction in postmenopausal cancer risk (relative risk, RR 0.90; 95% confidence interval, CI 0.82 to 0.99). Subgroup analyses showed consistent results for all potential confounding factors examined. Conclusions: Findings from this meta-analysis may support the hypothesis that coffee consumption is associated with decreased risk of postmenopausal breast cancer.

Original languageEnglish
Article number112
Issue number2
Publication statusPublished - Feb 1 2018


  • Breast cancer
  • Caffeine
  • Coffee
  • Dose-response
  • Meta-analysis
  • Postmenopausal
  • Receptor

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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