Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition

Saverio Caini, Giovanna Masala, Calogero Saieva, Marina Kvaskoff, Isabelle Savoye, Carlotta Sacerdote, Oskar Hemmingsson, Bodil Hammer Bech, Kim Overvad, Anne Tjønneland, Kristina E.N. Petersen, Francesca Romana Mancini, Marie Christine Boutron-Ruault, Iris Cervenka, Rudolf Kaaks, Tilman Kühn, Heiner Boeing, Anna Floegel, Antonia Trichopoulou, Elisavet ValanouMaria Kritikou, Giovanna Tagliabue, Salvatore Panico, Rosario Tumino, H. Bas Bueno-de-Mesquita, Petra H. Peeters, Marit B. Veierød, Reza Ghiasvand, Marko Lukic, José Ramón Quirós, Maria Dolores Chirlaque, Eva Ardanaz, Elena Salamanca Fernández, Nerea Larrañaga, Raul Zamora-Ros, Lena Maria Nilsson, Ingrid Ljuslinder, Karin Jirström, Emily Sonestedt, Timothy J. Key, Nick Wareham, Kay Tee Khaw, Marc Gunter, Inge Huybrechts, Neil Murphy, Konstantinos K. Tsilidis, Elisabete Weiderpass, Domenico Palli

Research output: Contribution to journalArticle

Abstract

In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25–70 years from ten European countries in 1992–2000. Information on coffee and tea drinking was collected at baseline using validated country-specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios (HR) and 95% confidence intervals (95% CI) for the associations between coffee and tea consumption and melanoma risk. Overall, 2,712 melanoma cases were identified during a median follow-up of 14.9 years among 476,160 study participants. Consumption of caffeinated coffee was inversely associated with melanoma risk among men (HR for highest quartile of consumption vs. non-consumers 0.31, 95% CI 0.14–0.69) but not among women (HR 0.96, 95% CI 0.62–1.47). There were no statistically significant associations between consumption of decaffeinated coffee or tea and the risk of melanoma among both men and women. The consumption of caffeinated coffee was inversely associated with melanoma risk among men in this large cohort study. Further investigations are warranted to confirm our findings and clarify the possible role of caffeine and other coffee compounds in reducing the risk of melanoma.

Original languageEnglish
Pages (from-to)2246-2255
Number of pages10
JournalInternational Journal of Cancer
Volume140
Issue number10
DOIs
Publication statusPublished - May 15 2017

Fingerprint

Coffee
Tea
Melanoma
Neoplasms
Confidence Intervals
Anticarcinogenic Agents
Caffeine
Proportional Hazards Models
Drinking
Multicenter Studies
Cohort Studies
Prospective Studies
Skin

Keywords

  • coffee
  • cohort study
  • melanoma
  • risk
  • tea

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Caini, S., Masala, G., Saieva, C., Kvaskoff, M., Savoye, I., Sacerdote, C., ... Palli, D. (2017). Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 140(10), 2246-2255. https://doi.org/10.1002/ijc.30659

Coffee, tea and melanoma risk : findings from the European Prospective Investigation into Cancer and Nutrition. / Caini, Saverio; Masala, Giovanna; Saieva, Calogero; Kvaskoff, Marina; Savoye, Isabelle; Sacerdote, Carlotta; Hemmingsson, Oskar; Hammer Bech, Bodil; Overvad, Kim; Tjønneland, Anne; Petersen, Kristina E.N.; Mancini, Francesca Romana; Boutron-Ruault, Marie Christine; Cervenka, Iris; Kaaks, Rudolf; Kühn, Tilman; Boeing, Heiner; Floegel, Anna; Trichopoulou, Antonia; Valanou, Elisavet; Kritikou, Maria; Tagliabue, Giovanna; Panico, Salvatore; Tumino, Rosario; Bueno-de-Mesquita, H. Bas; Peeters, Petra H.; Veierød, Marit B.; Ghiasvand, Reza; Lukic, Marko; Quirós, José Ramón; Chirlaque, Maria Dolores; Ardanaz, Eva; Salamanca Fernández, Elena; Larrañaga, Nerea; Zamora-Ros, Raul; Maria Nilsson, Lena; Ljuslinder, Ingrid; Jirström, Karin; Sonestedt, Emily; Key, Timothy J.; Wareham, Nick; Khaw, Kay Tee; Gunter, Marc; Huybrechts, Inge; Murphy, Neil; Tsilidis, Konstantinos K.; Weiderpass, Elisabete; Palli, Domenico.

In: International Journal of Cancer, Vol. 140, No. 10, 15.05.2017, p. 2246-2255.

Research output: Contribution to journalArticle

Caini, S, Masala, G, Saieva, C, Kvaskoff, M, Savoye, I, Sacerdote, C, Hemmingsson, O, Hammer Bech, B, Overvad, K, Tjønneland, A, Petersen, KEN, Mancini, FR, Boutron-Ruault, MC, Cervenka, I, Kaaks, R, Kühn, T, Boeing, H, Floegel, A, Trichopoulou, A, Valanou, E, Kritikou, M, Tagliabue, G, Panico, S, Tumino, R, Bueno-de-Mesquita, HB, Peeters, PH, Veierød, MB, Ghiasvand, R, Lukic, M, Quirós, JR, Chirlaque, MD, Ardanaz, E, Salamanca Fernández, E, Larrañaga, N, Zamora-Ros, R, Maria Nilsson, L, Ljuslinder, I, Jirström, K, Sonestedt, E, Key, TJ, Wareham, N, Khaw, KT, Gunter, M, Huybrechts, I, Murphy, N, Tsilidis, KK, Weiderpass, E & Palli, D 2017, 'Coffee, tea and melanoma risk: findings from the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 140, no. 10, pp. 2246-2255. https://doi.org/10.1002/ijc.30659
Caini, Saverio ; Masala, Giovanna ; Saieva, Calogero ; Kvaskoff, Marina ; Savoye, Isabelle ; Sacerdote, Carlotta ; Hemmingsson, Oskar ; Hammer Bech, Bodil ; Overvad, Kim ; Tjønneland, Anne ; Petersen, Kristina E.N. ; Mancini, Francesca Romana ; Boutron-Ruault, Marie Christine ; Cervenka, Iris ; Kaaks, Rudolf ; Kühn, Tilman ; Boeing, Heiner ; Floegel, Anna ; Trichopoulou, Antonia ; Valanou, Elisavet ; Kritikou, Maria ; Tagliabue, Giovanna ; Panico, Salvatore ; Tumino, Rosario ; Bueno-de-Mesquita, H. Bas ; Peeters, Petra H. ; Veierød, Marit B. ; Ghiasvand, Reza ; Lukic, Marko ; Quirós, José Ramón ; Chirlaque, Maria Dolores ; Ardanaz, Eva ; Salamanca Fernández, Elena ; Larrañaga, Nerea ; Zamora-Ros, Raul ; Maria Nilsson, Lena ; Ljuslinder, Ingrid ; Jirström, Karin ; Sonestedt, Emily ; Key, Timothy J. ; Wareham, Nick ; Khaw, Kay Tee ; Gunter, Marc ; Huybrechts, Inge ; Murphy, Neil ; Tsilidis, Konstantinos K. ; Weiderpass, Elisabete ; Palli, Domenico. / Coffee, tea and melanoma risk : findings from the European Prospective Investigation into Cancer and Nutrition. In: International Journal of Cancer. 2017 ; Vol. 140, No. 10. pp. 2246-2255.
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abstract = "In vitro and animal studies suggest that bioactive constituents of coffee and tea may have anticarcinogenic effects against cutaneous melanoma; however, epidemiological evidence is limited to date. We examined the relationships between coffee (total, caffeinated or decaffeinated) and tea consumption and risk of melanoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a multicentre prospective study that enrolled over 500,000 participants aged 25–70 years from ten European countries in 1992–2000. Information on coffee and tea drinking was collected at baseline using validated country-specific dietary questionnaires. We used adjusted Cox proportional hazards regression models to calculate hazard ratios (HR) and 95{\%} confidence intervals (95{\%} CI) for the associations between coffee and tea consumption and melanoma risk. Overall, 2,712 melanoma cases were identified during a median follow-up of 14.9 years among 476,160 study participants. Consumption of caffeinated coffee was inversely associated with melanoma risk among men (HR for highest quartile of consumption vs. non-consumers 0.31, 95{\%} CI 0.14–0.69) but not among women (HR 0.96, 95{\%} CI 0.62–1.47). There were no statistically significant associations between consumption of decaffeinated coffee or tea and the risk of melanoma among both men and women. The consumption of caffeinated coffee was inversely associated with melanoma risk among men in this large cohort study. Further investigations are warranted to confirm our findings and clarify the possible role of caffeine and other coffee compounds in reducing the risk of melanoma.",
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AU - Savoye, Isabelle

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AU - Hemmingsson, Oskar

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AU - Trichopoulou, Antonia

AU - Valanou, Elisavet

AU - Kritikou, Maria

AU - Tagliabue, Giovanna

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Bueno-de-Mesquita, H. Bas

AU - Peeters, Petra H.

AU - Veierød, Marit B.

AU - Ghiasvand, Reza

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AU - Sonestedt, Emily

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AU - Huybrechts, Inge

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