Abstract
Purpose To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment. Design Interventional case report. Methods Institutional setting. Results Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other. Conclusion When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result.
| Original language | English |
|---|---|
| Pages (from-to) | 757-758 |
| Number of pages | 2 |
| Journal | American Journal of Ophthalmology |
| Volume | 137 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Apr 2004 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Cogan syndrome in children : Early diagnosis and treatment is critical to prognosis. / Orsoni, Jelka G.; Zavota, Laura; Vincenti, Vincenzo; Pellistri, Isabella; Rama, Paolo.
In: American Journal of Ophthalmology, Vol. 137, No. 4, 04.2004, p. 757-758.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cogan syndrome in children
T2 - Early diagnosis and treatment is critical to prognosis
AU - Orsoni, Jelka G.
AU - Zavota, Laura
AU - Vincenti, Vincenzo
AU - Pellistri, Isabella
AU - Rama, Paolo
PY - 2004/4
Y1 - 2004/4
N2 - Purpose To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment. Design Interventional case report. Methods Institutional setting. Results Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other. Conclusion When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result.
AB - Purpose To present two cases of pediatric Cogan Syndrome and to highlight the differences between the adult and pediatric forms of the disease, as well as the importance of early diagnosis and treatment. Design Interventional case report. Methods Institutional setting. Results Corneal lesions were much more diffuse than those observed in adult Cogan syndrome. Immunosuppressive drug combination therapy successfully resolved systemic and ocular inflammation, but the involvement of the pupillary area caused permanent low vision in one case and amblyopia in the other. Conclusion When chronic ocular inflammation is observed in association with sensory neural hearing loss and any systemic signs of autoimmune inflammation, a diagnosis of Cogan syndrome should be suspected. If immunosuppressive treatment is not initiated as soon as possible, permanent low vision and deafness can result.
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U2 - 10.1016/j.ajo.2003.09.034
DO - 10.1016/j.ajo.2003.09.034
M3 - Article
VL - 137
SP - 757
EP - 758
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 4
ER -