COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer

I. P M Tomlinson, M. Dunlop, H. Campbell, B. Zanke, S. Gallinger, T. Hudson, T. Koessler, P. D. Pharoah, I. Niittymäkix, S. Tuupanenx, L. A. Aaltonen, K. Hemminki, A. Lindblom, A. Försti, O. Sieber, L. Lipton, T. Van Wezel, H. Morreau, J. T. Wijnen, P. DevileeK. Matsuda, Y. Nakamura, S. Castellví-Bel, C. Ruiz-Ponte, A. Castells, A. Carracedo, J. W C Ho, P. Sham, R. M W Hofstra, P. Vodicka, H. Brenner, J. Hampe, C. Schafmayer, J. Tepel, S. Schreiber, H. Völzke, M. M. Lerch, C. A. Schmidt, S. Buch, V. Moreno, C. M. Villanueva, P. Peterlongo, P. Radice, M. M. Echeverry, A. Velez, L. Carvajal-Carmona, R. Scott, S. Penegar, P. Broderick, A. Tenesa, R. S. Houlston

Research output: Contribution to journalArticle

Abstract

It is now recognised that a part of the inherited risk of colorectal cancer (CRC) can be explained by the co-inheritance of low-penetrance genetic variants. The accumulated experience to date in identifying these variants has served to highlight difficulties in conducting statistically and methodologically rigorous studies and follow-up analyses. The COGENT (COlorectal cancer GENeTics) consortium includes 20 research groups in Europe, Australia, the Americas, China and Japan. The overarching goal of COGENT is to identify and characterise low-penetrance susceptibility variants for CRC through association-based analyses. In this study, we review the rationale for identifying low-penetrance variants for CRC and our proposed strategy for establishing COGENT.

Original languageEnglish
Pages (from-to)447-454
Number of pages8
JournalBritish Journal of Cancer
Volume102
Issue number2
DOIs
Publication statusPublished - Jan 2010

Keywords

  • Association
  • Colorectal cancer
  • Polymorphism

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Tomlinson, I. P. M., Dunlop, M., Campbell, H., Zanke, B., Gallinger, S., Hudson, T., Koessler, T., Pharoah, P. D., Niittymäkix, I., Tuupanenx, S., Aaltonen, L. A., Hemminki, K., Lindblom, A., Försti, A., Sieber, O., Lipton, L., Van Wezel, T., Morreau, H., Wijnen, J. T., ... Houlston, R. S. (2010). COGENT (COlorectal cancer GENeTics): An international consortium to study the role of polymorphic variation on the risk of colorectal cancer. British Journal of Cancer, 102(2), 447-454. https://doi.org/10.1038/sj.bjc.6605338