Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease

Gianfranco Spalletta, Francesca Baldinetti, Ivana Buccione, Lucia Fadda, Roberta Perri, Silvia Scalmana, Laura Serra, Carlo Caltagirone

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

Clinical expressions of cognition and behaviour in Alzheimer's disease (AD) patients are heterogeneous. Therefore, as sessing the entire range of selective cognitive and behavioural characteristics of dementia in minute detail is extremely important. However, considering that groups of different symptoms may respond to the same pharmacological agent, it is also evident that a correct evaluation of the behaviour requires the grouping of symptoms in fewer syndromes. Thus, the authors have analysed various connections between selective cognitive domains and behavioural symptoms (BPSD) in probable AD outpatients. Two hundred and forty four patients with diagnosis of probable AD, according to DSM-IV and NINCDS-ADRDA criteria were enrolled. The evaluation included the Mini Mental State Examination, the Mental Deterioration Battery, and the Neuropsychiatric Inventory. Treatment with low doses of neuroleptic drugs only was allowed. Principal component analysis condensed the 18 cognitive/behavioural variables in 7 factors namely general-cognitive, constructional abilities, hyperactivity, psychosis, anxiety, mood-excitement and mood-depression/ apathy. None of the cognitive domains were included in the behavioural factors and vice-versa. Furthermore, the only BPSD which impaired continuously with progression of disease severity was apathy which was also the most severe symptom. In conclusion, many cognitive and behavioural syndromes exist in patients with AD. However, the results of this study suggest that cognition and behaviour are independent dimensions.

Original languageEnglish
Pages (from-to)688-695
Number of pages8
JournalJournal of Neurology
Volume251
Issue number6
Publication statusPublished - Jun 2004

Fingerprint

Cognition
Alzheimer Disease
Apathy
Behavioral Symptoms
Neurobehavioral Manifestations
Aptitude
Principal Component Analysis
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Antipsychotic Agents
Dementia
Disease Progression
Outpatients
Anxiety
Pharmacology
Depression
Equipment and Supplies
Therapeutics

Keywords

  • AD
  • BPSD
  • Cognition
  • Dimension
  • Syndrome

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease. / Spalletta, Gianfranco; Baldinetti, Francesca; Buccione, Ivana; Fadda, Lucia; Perri, Roberta; Scalmana, Silvia; Serra, Laura; Caltagirone, Carlo.

In: Journal of Neurology, Vol. 251, No. 6, 06.2004, p. 688-695.

Research output: Contribution to journalArticle

Spalletta, Gianfranco ; Baldinetti, Francesca ; Buccione, Ivana ; Fadda, Lucia ; Perri, Roberta ; Scalmana, Silvia ; Serra, Laura ; Caltagirone, Carlo. / Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease. In: Journal of Neurology. 2004 ; Vol. 251, No. 6. pp. 688-695.
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