Cognitive and affective theory of mind in patients with essential tremor

Gabriella Santangelo, Luigi Trojano, Paolo Barone, Domenico Errico, Ilaria Improta, Valeria Agosti, Dario Grossi, Giuseppe Sorrentino, Carmine Vitale

Research output: Contribution to journalArticle

Abstract

The theory of mind (ToM) is the ability to attribute mental states to oneself and others and to understand that others have beliefs, desires and intentions different from one's own. The aim of the present study was to explore the neuropsychological correlates of cognitive and affective ToM in patients affected by essential tremor (ET). Thirty consecutive ET outpatients and 30 healthy age-, sex- and education-matched control subjects underwent tasks assessing short-term memory, verbal learning and executive functions, as well as tasks assessing "cognitive" and "affective" ToM; questionnaires evaluating behavioral disorders and quality of life were also administered. Although the two groups did not differ on demographic variables, ET patients scored worse on memory tasks, and showed more apathy and worse quality of life than controls. After covarying for mnestic, behavioral and quality of life scores, ET patients achieved significantly lower scores than controls on task assessing cognitive ToM, whereas no difference was found between the two groups on task assessing affective ToM. In ET, "Cognitive" ToM was significantly associated with frontal tasks, whereas "Affective" ToM was not correlated with cognitive, behavioral or quality of life scales. Our results indicate that cognitive aspects of ToM may be selectively impaired in ET. Possible underlying neural mechanisms of the deficits are discussed.

Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalJournal of Neurology
Volume260
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Apathy
  • Cognitive dysfunctions
  • Essential tremor
  • Quality of life
  • Theory of mind

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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    Santangelo, G., Trojano, L., Barone, P., Errico, D., Improta, I., Agosti, V., Grossi, D., Sorrentino, G., & Vitale, C. (2013). Cognitive and affective theory of mind in patients with essential tremor. Journal of Neurology, 260(2), 513-520. https://doi.org/10.1007/s00415-012-6668-2