Cognitive and behavioral determinants of psychotic symptoms in Alzheimer's disease

Davide Quaranta, Maria Gabriella Vita, Alessandra Bizzarro, Carlo Masullo, Chiara Piccininni, Guido Gainotti, Camillo Marra

Research output: Contribution to journalArticle

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Abstract

Aims: To investigate the relationship between psychotic symptoms and cognitive impairment in Alzheimer's disease (AD). Methods: A total of 108 subjects affected by AD were subdivided into subjects without delusions (ND), subjects with paranoid delusions (PD), subjects with delusional misidentifications (DM), subjects with both DM and PD (DM+PD), subjects with visual hallucinations (v-HALL), and subjects without visual hallucinations (N-HALL). Results: PD and ND subjects performed similarly on neuropsychological tests, while DM patients performed significantly worse than PD and ND patients. v-HALL patients performed worse than N-HALL patients on memory, visuospatial, and executive functions. As for behavioral features, DM and v-HALL subjects reported higher scores on the abnormal motor behavior subscale of the neuropsychiatric inventory (NPI); PD subjects reported higher scores on the disinhibition subscale of the NPI. The severity of PD was predicted by the severity of disinhibition (B = 0.514; p = 0.016) but not by neuropsychological performances. The severity of DM was predicted by age (B = 0.099; p = 0.048) and MMSE (B = -0.233; p = 0.001). The severity of v-HALL was predicted by age (B = 0.052; p = 0.037) and scores on an immediate visual memory task (B = -0.135; p = 0.007). Conclusions: The occurrence of PD may require the relative sparing of cognitive functions and be favored by frontal lobe dysfunction, while DM is associated with the overall level of cognitive impairment. Finally, v-HALL are associated with the impairment of visuospatial abilities.

Original languageEnglish
Pages (from-to)194-206
Number of pages13
JournalDementia and Geriatric Cognitive Disorders
Volume39
Issue number3-4
DOIs
Publication statusPublished - Apr 18 2015

Fingerprint

Delusions
Alzheimer Disease
Hallucinations
Equipment and Supplies
Aptitude
Neuropsychological Tests
Executive Function
Frontal Lobe
Short-Term Memory
Cognition

Keywords

  • Alzheimer's disease
  • Delusional misidentifications
  • Delusions
  • Hallucinations
  • Neuropsychological assessment
  • Psychosis

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Medicine(all)

Cite this

Quaranta, D., Vita, M. G., Bizzarro, A., Masullo, C., Piccininni, C., Gainotti, G., & Marra, C. (2015). Cognitive and behavioral determinants of psychotic symptoms in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 39(3-4), 194-206. https://doi.org/10.1159/000369161

Cognitive and behavioral determinants of psychotic symptoms in Alzheimer's disease. / Quaranta, Davide; Vita, Maria Gabriella; Bizzarro, Alessandra; Masullo, Carlo; Piccininni, Chiara; Gainotti, Guido; Marra, Camillo.

In: Dementia and Geriatric Cognitive Disorders, Vol. 39, No. 3-4, 18.04.2015, p. 194-206.

Research output: Contribution to journalArticle

Quaranta, D, Vita, MG, Bizzarro, A, Masullo, C, Piccininni, C, Gainotti, G & Marra, C 2015, 'Cognitive and behavioral determinants of psychotic symptoms in Alzheimer's disease', Dementia and Geriatric Cognitive Disorders, vol. 39, no. 3-4, pp. 194-206. https://doi.org/10.1159/000369161
Quaranta D, Vita MG, Bizzarro A, Masullo C, Piccininni C, Gainotti G et al. Cognitive and behavioral determinants of psychotic symptoms in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 2015 Apr 18;39(3-4):194-206. https://doi.org/10.1159/000369161
Quaranta, Davide ; Vita, Maria Gabriella ; Bizzarro, Alessandra ; Masullo, Carlo ; Piccininni, Chiara ; Gainotti, Guido ; Marra, Camillo. / Cognitive and behavioral determinants of psychotic symptoms in Alzheimer's disease. In: Dementia and Geriatric Cognitive Disorders. 2015 ; Vol. 39, No. 3-4. pp. 194-206.
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