Cognitive and behavioural predictors of progression rates in Alzheimer's disease

I. Buccione, R. Perri, G. A. Carlesimo, L. Fadda, L. Serra, S. Scalmana, C. Caltagirone

Research output: Contribution to journalArticlepeer-review


Cognitive and functional decline in Alzheimer's disease (AD) may show different, yet correlated, rates of progression. Over a 2-year period we investigated the predictive role of neuropsychological and behavioural variables on the cognitive and functional decline of 43 patients with AD. Slow and fast decliners were defined on the basis of cognitive and functional indexes of disease progression. We found that cognitive decline was predicted by diffuse cognitive impairment and functional progression by visuospatial deficits. Psychotic symptoms predicted faster disease progression in both cognitive and functional dimensions.

Original languageEnglish
Pages (from-to)440-446
Number of pages7
JournalEuropean Journal of Neurology
Issue number4
Publication statusPublished - Apr 2007


  • Alzheimer's disease
  • Clinical features
  • Dementia
  • Neuropsychology

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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