Cognitive and neural determinants of response strategy in the dual-solution plus-maze task

Elvira De Leonibus; Vivian J A Costantini; Antonio Massaro; Georgia Mandolesi; Valentina Vanni; Siro Luvisetto; Flaminia Pavone; Alberto Oliverio; Andrea Mele

doi:10.1101/lm.2074311

Cognitive and neural determinants of response strategy in the dual-solution plus-maze task

Elvira De Leonibus, Vivian J A Costantini, Antonio Massaro, Georgia Mandolesi, Valentina Vanni, Siro Luvisetto, Flaminia Pavone, Alberto Oliverio, Andrea Mele

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Response strategy in the dual-solution plus maze is regarded as a form of stimulus-response learning. In this study, by using an outcome devaluation procedure, we show that it can be based on both action-outcome and stimulus-response habit learning, depending on the amount of training that the animals receive. Furthermore, we show that deactivation of the dorsomedial and the dorso-lateral striatum with Botulinum neurotoxin A, mimicked or abolished, respectively, the effects of practice on the sensitivity of the response strategy to outcome devaluation. These findings have relevant implications for the understanding of the learning mechanisms underlying different overt behaviors in this widely used maze task.

Original language	English
Pages (from-to)	241-244
Number of pages	4
Journal	Learning and Memory
Volume	18
Issue number	4
DOIs	https://doi.org/10.1101/lm.2074311
Publication status	Published - Apr 2011

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience
Neuropsychology and Physiological Psychology

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Cognitive and neural determinants of response strategy in the dual-solution plus-maze task. / De Leonibus, Elvira; Costantini, Vivian J A; Massaro, Antonio; Mandolesi, Georgia ; Vanni, Valentina; Luvisetto, Siro; Pavone, Flaminia; Oliverio, Alberto; Mele, Andrea.

In: Learning and Memory, Vol. 18, No. 4, 04.2011, p. 241-244.

Research output: Contribution to journal › Article › peer-review

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