Cognitive and neural determinants of response strategy in the dual-solution plus-maze task

Elvira De Leonibus, Vivian J A Costantini, Antonio Massaro, Georgia Mandolesi, Valentina Vanni, Siro Luvisetto, Flaminia Pavone, Alberto Oliverio, Andrea Mele

Research output: Contribution to journalArticlepeer-review

Abstract

Response strategy in the dual-solution plus maze is regarded as a form of stimulus-response learning. In this study, by using an outcome devaluation procedure, we show that it can be based on both action-outcome and stimulus-response habit learning, depending on the amount of training that the animals receive. Furthermore, we show that deactivation of the dorsomedial and the dorso-lateral striatum with Botulinum neurotoxin A, mimicked or abolished, respectively, the effects of practice on the sensitivity of the response strategy to outcome devaluation. These findings have relevant implications for the understanding of the learning mechanisms underlying different overt behaviors in this widely used maze task.

Original languageEnglish
Pages (from-to)241-244
Number of pages4
JournalLearning and Memory
Volume18
Issue number4
DOIs
Publication statusPublished - Apr 2011

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Neuropsychology and Physiological Psychology

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