Cognitive and psychosocial features in childhood and juvenile MS

Two-year follow-up

M. P. Amato, B. Goretti, A. Ghezzi, S. Lori, V. Zipoli, L. Moiola, M. Falautano, M. F. De Caro, R. Viterbo, F. Patti, R. Vecchio, C. Pozzilli, V. Bianchi, M. Roscio, V. Martinelli, G. Comi, E. Portaccio, M. Trojano

Research output: Contribution to journalArticle

132 Citations (Scopus)

Abstract

Objective: To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation. Methods: In this cohort study, we used the same extensive neuropsychological battery with alternative versions of the tests assessing memory, attention/concentration, executive functions, and language. Fatigue and depression were also measured. An interview on school and daily living activities was obtained from the parents. The cognitive performance of the patients was compared with that of demographically matched healthy controls (Hc). Results: Fifty-six patients and 50 HC were assessed. At follow-up, criteria for cognitive impairment (failure on at least 3 tests) were fulfilled in 39 patients (70%) and 75% of the cases were classified as having a deteriorating cognitive performance. Changes were prominent in tests of verbal memory, complex attention, verbal fluency, and receptive language. In the regression analysis, the only significant predictor of cognitive deterioration was older age of the subject (odds ratio 1.9, 95% confidence interval 1.2-2.9, p = 0.003). Psychiatric disorders, most frequently depression, were diagnosed in 12 patients (30.5%). Fatigue was reported by 21% of the patients. MS negatively affected school and everyday activities in 30% to 40% of the subjects. Conclusions: Our findings confirm the importance of systematic assessment of cognitive and psychosocial issues in children and teens with MS. The progressive nature of the cognitive difficulties emphasizes the need for developing effective treatment strategies.

Original languageEnglish
Pages (from-to)1134-1140
Number of pages7
JournalNeurology
Volume75
Issue number13
DOIs
Publication statusPublished - Sep 28 2010

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Multiple Sclerosis
Fatigue
Language
Depression
Executive Function
Activities of Daily Living
Psychiatry
Cohort Studies
Parents
Odds Ratio
Regression Analysis
Confidence Intervals
Interviews
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Amato, M. P., Goretti, B., Ghezzi, A., Lori, S., Zipoli, V., Moiola, L., ... Trojano, M. (2010). Cognitive and psychosocial features in childhood and juvenile MS: Two-year follow-up. Neurology, 75(13), 1134-1140. https://doi.org/10.1212/WNL.0b013e3181f4d821

Cognitive and psychosocial features in childhood and juvenile MS : Two-year follow-up. / Amato, M. P.; Goretti, B.; Ghezzi, A.; Lori, S.; Zipoli, V.; Moiola, L.; Falautano, M.; De Caro, M. F.; Viterbo, R.; Patti, F.; Vecchio, R.; Pozzilli, C.; Bianchi, V.; Roscio, M.; Martinelli, V.; Comi, G.; Portaccio, E.; Trojano, M.

In: Neurology, Vol. 75, No. 13, 28.09.2010, p. 1134-1140.

Research output: Contribution to journalArticle

Amato, MP, Goretti, B, Ghezzi, A, Lori, S, Zipoli, V, Moiola, L, Falautano, M, De Caro, MF, Viterbo, R, Patti, F, Vecchio, R, Pozzilli, C, Bianchi, V, Roscio, M, Martinelli, V, Comi, G, Portaccio, E & Trojano, M 2010, 'Cognitive and psychosocial features in childhood and juvenile MS: Two-year follow-up', Neurology, vol. 75, no. 13, pp. 1134-1140. https://doi.org/10.1212/WNL.0b013e3181f4d821
Amato, M. P. ; Goretti, B. ; Ghezzi, A. ; Lori, S. ; Zipoli, V. ; Moiola, L. ; Falautano, M. ; De Caro, M. F. ; Viterbo, R. ; Patti, F. ; Vecchio, R. ; Pozzilli, C. ; Bianchi, V. ; Roscio, M. ; Martinelli, V. ; Comi, G. ; Portaccio, E. ; Trojano, M. / Cognitive and psychosocial features in childhood and juvenile MS : Two-year follow-up. In: Neurology. 2010 ; Vol. 75, No. 13. pp. 1134-1140.
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abstract = "Objective: To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation. Methods: In this cohort study, we used the same extensive neuropsychological battery with alternative versions of the tests assessing memory, attention/concentration, executive functions, and language. Fatigue and depression were also measured. An interview on school and daily living activities was obtained from the parents. The cognitive performance of the patients was compared with that of demographically matched healthy controls (Hc). Results: Fifty-six patients and 50 HC were assessed. At follow-up, criteria for cognitive impairment (failure on at least 3 tests) were fulfilled in 39 patients (70{\%}) and 75{\%} of the cases were classified as having a deteriorating cognitive performance. Changes were prominent in tests of verbal memory, complex attention, verbal fluency, and receptive language. In the regression analysis, the only significant predictor of cognitive deterioration was older age of the subject (odds ratio 1.9, 95{\%} confidence interval 1.2-2.9, p = 0.003). Psychiatric disorders, most frequently depression, were diagnosed in 12 patients (30.5{\%}). Fatigue was reported by 21{\%} of the patients. MS negatively affected school and everyday activities in 30{\%} to 40{\%} of the subjects. Conclusions: Our findings confirm the importance of systematic assessment of cognitive and psychosocial issues in children and teens with MS. The progressive nature of the cognitive difficulties emphasizes the need for developing effective treatment strategies.",
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AU - Goretti, B.

AU - Ghezzi, A.

AU - Lori, S.

AU - Zipoli, V.

AU - Moiola, L.

AU - Falautano, M.

AU - De Caro, M. F.

AU - Viterbo, R.

AU - Patti, F.

AU - Vecchio, R.

AU - Pozzilli, C.

AU - Bianchi, V.

AU - Roscio, M.

AU - Martinelli, V.

AU - Comi, G.

AU - Portaccio, E.

AU - Trojano, M.

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N2 - Objective: To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation. Methods: In this cohort study, we used the same extensive neuropsychological battery with alternative versions of the tests assessing memory, attention/concentration, executive functions, and language. Fatigue and depression were also measured. An interview on school and daily living activities was obtained from the parents. The cognitive performance of the patients was compared with that of demographically matched healthy controls (Hc). Results: Fifty-six patients and 50 HC were assessed. At follow-up, criteria for cognitive impairment (failure on at least 3 tests) were fulfilled in 39 patients (70%) and 75% of the cases were classified as having a deteriorating cognitive performance. Changes were prominent in tests of verbal memory, complex attention, verbal fluency, and receptive language. In the regression analysis, the only significant predictor of cognitive deterioration was older age of the subject (odds ratio 1.9, 95% confidence interval 1.2-2.9, p = 0.003). Psychiatric disorders, most frequently depression, were diagnosed in 12 patients (30.5%). Fatigue was reported by 21% of the patients. MS negatively affected school and everyday activities in 30% to 40% of the subjects. Conclusions: Our findings confirm the importance of systematic assessment of cognitive and psychosocial issues in children and teens with MS. The progressive nature of the cognitive difficulties emphasizes the need for developing effective treatment strategies.

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